The purpose of this study was to quantify overall blood flow and renal cortical perfusion in patients with septic acute kidney injury (AKI) using ultrasound (US) Doppler and contrast-enhanced ultrasound (CEUS).
Kidney ultrasound is the most widely used imaging modality in initial AKI workup as it is widely available and free of complications. It is clinically feasible to use US Doppler and contrast-enhanced US (CEUS) to detect macroscopic and microscopic changes in renal blood flow, and also cardiac output alterations.The aim was to analyze changes in US Doppler and CEUS quantitative parameters in patients with septic AKI to explore perfusion within the renal parenchyma, and also measure global renal blood flow and cardiac output.
Study Type
OBSERVATIONAL
Enrollment
100
Patients are diagnosed by intravenous injection of ultrasound contrast on the first day of admission and information is collected by diagnostic ultrasound instruments
The Second Hospital of Soochow University
Suzhou, Jiangsu, China
RECRUITINGUltrasound Doppler parameters
Time-averaged velocity (TAV)in cm/s
Time frame: First 24 hours after admission
Ultrasound Doppler parameters
Relative blood flow（RBF）in L/min
Time frame: First 24 hours after admission
Ultrasonography parameters
Time to peak (TTP)in senconds
Time frame: First 24 hours after admission
Ultrasonography parameters
Maximum intensity (Imax)in a.u（Acoustic intensity units）
Time frame: First 24 hours after admission
Ultrasonography parameters
area under curve is the multiplication of acoustic intensity and time（a.u\*s）
Time frame: First 24 hours after admission
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