Evaluation Of Stress Response In Diabetic Hypertensive Patients

Istanbul University62 enrolled

Overview

In this research, we aimed to examine salivary cortisol changes in the cognitive stress response of patients with Hypertension + Diabetes Mellitus (HT+DM) and Hypertension (HT) and to determine the differences between them. The research was conducted by solving an arithmetic task as a stress test in 62 patients with HT+DM and HT that are being treated in the outpatient clinic of Medical Pharmacology and Clinical Pharmacology Department at Istanbul University, Istanbul Medical Faculty Hospital.

In this study, saliva samples were taken for cortisol measurement, and patients were instructed to place the cotton piece in the salivette® tubes directly into their mouths without touching it with anything, hold it for 30-60 seconds, and then insert it back into the tubes in the same way, four times total, once before arithmetic stress and three times after stress, on Tuesdays, Wednesdays, and Thursdays between the hours of 12:00-16:00. Salivary cortisol was measured using the electro-chemiluminescence immunoassay.

Study Type

OBSERVATIONAL

Enrollment

Conditions

Diabetes Hypertension

Interventions

First arithmetic problem solvingBEHAVIORAL

In a quiet environment, a white paper in A4 format was placed in front of the patient on the table, and the patients were asked to subtract the number 3 from 2907 for 100 seconds. The researcher was standing in front of the patient and asks to make corrections by giving a warning whenever the patient made a mistake in the calculation.

Second arithmetic problem solvingBEHAVIORAL

In the same A4-sized white paper that was placed in front of each patient on a table, immediately after the first subtraction process, patients were asked to subtract 7 from 6828 for another 100 seconds. When the patient made a calculating error, the researcher stood in front of the patient and asked them to make corrections by issuing a warning.

Third arithmetic problem solving

Eligibility

Sex: MALEMin age: 40 YearsMax age: 65 Years

Medical Language ↔ Plain English

Inclusion Criteria: 1. Using antihypertensive treatment for the last 3 months 2. Diagnosed with Type 2 Diabetes Mellitus and taking medication for at least 3 months 3. Being between the ages of 40-65 4. Being male 5. Having signed the informed consent form Exclusion Criteria: 1. Female gender 2. Patients younger than 40 years old or older than 65 years old 3. Uncontrolled blood pressure (SBP\>140 mmHg, DBP\>90 mmHg) 4. Using antipsychotic medication 5. Using current treatment for less than 3 months 6. Having a previous MI 7. Having a previous stroke 8. Having a lung disease 9. Having organ failure 10. Having Cushing's disease 11. Having aldosteronism 12. Failure to sign the informed consent form

Locations (1)

Istanbul University

Istanbul, Turkey (Türkiye)

Outcomes

Primary Outcomes

Cortisol

A saliva sample is collected for cortisol evaluation

Time frame: Baseline

Cortisol

A saliva sample is collected

Time frame: 30 minutes after beginning

Cortisol

A saliva sample is collected

Time frame: 45 minutes after beginning

Cortisol

A saliva sample is collected

Time frame: 60 minutes after beginning

Blood pressure