Machine Perfusion in High vs Low/Mid-volume Liver Transplant Centers: a Multicentre Survey

Roberta Angelico67 enrolled

Overview

Introduction: Machine perfusion (MP) was developed to expand the available donor pool and to improve liver transplantation outcomes. Despite optimal results in clinical trials, MP benefit outside of clinical experimentation in unknown. Low/mid volume centres (L/MVCs) may face logistical/economical difficulties that may in turn hamper optimal MP results. Methods: An Online 22-item survey on the use of machine perfusion for liver transplantation outside of clinical trials, was distributed to worldwide LT centres representatives. Variables of interest included MP logistics, MP technicalities, MP results, post-MP LT results. Responding centres were grouped into high volume centre (HVCs)(defined as \>60 LTs per year in 2019) and L/MVCs. Results from HVCs vs L/MVCs were compared.

Study Type

OBSERVATIONAL

Enrollment

Conditions

Organ Preservation Solution

Interventions

MACHINE PERFUSIONDEVICE

Different outcomes of MP use in low/mid-volume and high-volume LT centres

Eligibility

Medical Language ↔ Plain English

Inclusion Criteria: * LT centres that use MP * LT centres which perform LT before pandemic time (before 2019 included) * LT centres which perform LT from cadaveric donors and living donors Exclusion Criteria: * LT centres that not use MP * LT centres that use MP but on clinical trials

Outcomes

Primary Outcomes

Liver transplant(LT) centres different use of graft after utilization of machine perfusion (MP)

High Volume Centers and Low/Mid Volume centers differ in their rates of graft utilization after Machine perfusion

Time frame: 12/2021 - 03/2022

Secondary Outcomes

Liver Transplant outcomes after Machine Perfusion

Reported patient survival rates for Liver Transplant after Machine Perfusion