In the pathophysiology of insomnia, the increase of the orexin-A (OXA) peptide released from orexin neurons in the lateral hypothalamus plays an important role. Orexins takes part at the emergence of anesthesia. In the literature, investigators could not attain any studies about the arousal of insomnia patients from anesthesia. In this study, the effect of this peptide on the emergence process from anesthesia was investigated by comparing plasma OXA levels before and after anesthesia in insomnia patients.
ASA (American Society of Anesthesiologists) I-II patients aged 18-65 years who underwent elective laparoscopic cholecystectomy were included in the study. Patients were evaluated with the Jenkins Sleep Disorders scale and Epworth Sleepiness scale during preoperative examination and were divided into insomnia and control groups. Blood samples were obtained for OXA and glucose levels at anesthesia induction, 5 minutes after extubation and 30 minutes after extubation. The times from stopping anesthesia to eyes opening and extubation and end-tidal sevoflurane concentrations at these time points were recorded.
Study Type
OBSERVATIONAL
Enrollment
60
Jenkins Sleep Disorders scale and Epworth Sleepiness scale
Mugla Sitki Kocman University
Muğla, Turkey (Türkiye)
Orexin-A Levels
plasma OXA levels anesthesia induction and after anesthesia in insomnia patients
Time frame: at anesthesia induction, 5 minutes after extubation and 30 minutes after extubation
Orexin-A Levels
plasma OXA levels anesthesia induction and after anesthesia in control group
Time frame: at anesthesia induction, 5 minutes after extubation and 30 minutes after extubation
recovery time from general anesthesia
The relationship between plasma OXA levels and recovery times from anesthesia in insomnia patients
Time frame: time of eyes opening and time of extubation
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