Investigators use clinical trial to explore the role of sarcopenia and multimodal rehabilitation in prognosis of rectal cancer patients receiving concurrent chemoradiotherapy.
The impact of sarcopenia and the effect of multimodal rehabilitation will be evaluated in the rectal cancer patients receiving pre-operative concurrent chemoradiotherapy. This is a randomized trial.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
SUPPORTIVE_CARE
Masking
SINGLE
Enrollment
100
for excise, nutrition consultant, nutrition supplement and psychologic intervention.
Chang Gung Memorial Hospital
Kaohsiung City, Taiwan
Sarcopenia assessment with muscle power
Assessment with Grip strength(Kg)
Time frame: baseline
Sarcopenia assessment with muscle power
Assessment with Grip strength(Kg)
Time frame: 1.5 months later
Sarcopenia assessment with muscle power
Assessment with Grip strength(Kg)
Time frame: 3 months later
Sarcopenia assessment with speed
Assessment with speed(m/s)
Time frame: baseline
Sarcopenia assessment with speed
Assessment with speed(m/s)
Time frame: 1.5 months later
Sarcopenia assessment with speed
Assessment with speed(m/s)
Time frame: 3 months later
Sarcopenia assessment with DXA
Assessment with DXA(g/cm2)
Time frame: baseline
Sarcopenia assessment with DXA
Assessment with DXA(g/cm2)
Time frame: 3 months later
Sarcopenia assessment with abdominal CT
Assessment with ASM/heigh2(Kg/m2) of L3 level
Time frame: baseline
Sarcopenia assessment with abdominal CT
Assessment with ASM/heigh2(Kg/m2) of L3 level
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Time frame: 3 months later
Nutrition assessment with albuminemia
albumin level in serum
Time frame: baseline
Nutrition assessment with albuminemia
albumin level in serum
Time frame: 1.5 months later
Nutrition assessment with albuminemia
albumin level in serum
Time frame: 3 months later
Nutrition assessment with pre-albuminemia
pre-albumin level in serum
Time frame: baseline
Nutrition assessment with pre-albuminemia
pre-albumin level in serum
Time frame: 1.5 months later
Nutrition assessment with pre-albuminemia
pre-albumin level in serum
Time frame: 3 months later
Nutrition assessment with PGSGA
patient-generated subjective global assessment Scale (Total score 0\~9 ;score 1-3 Good nutritional intake. score 4-8 Moderate malnutrition. score \>9Severe malnutrition)
Time frame: baseline
Nutrition assessment with PGSGA
patient-generated subjective global assessment Scale (Total score 0\~9 ;score 1-3 Good nutritional intake. score 4-8 Moderate malnutrition. score \>9Severe malnutrition)
Time frame: 1.5 months later
Nutrition assessment with PGSGA
patient-generated subjective global assessment Scale (Total score 0\~9 ;score 1-3 Good nutritional intake. score 4-8 Moderate malnutrition. score \>9Severe malnutrition)
Time frame: 3 months later
Psychological assessment
Taiwanese Depression Questionnaire (TDQ)Total score 0-54; score \>8 emotionally stable ;Score 9 \~ 14 Pay attention to emotional changes Score 15 \~ 18 pressure load reaches the critical point; Score 19-28 It is recommended to find a professional institution or medical unit assistance ;Scores 29 or more must find professional medical units to get involved
Time frame: baseline
Psychological assessment
Taiwanese Depression Questionnaire (TDQ)Total score 0-54; score \>8 emotionally stable ;Score 9 \~ 14 Pay attention to emotional changes Score 15 \~ 18 pressure load reaches the critical point; Score 19-28 It is recommended to find a professional institution or medical unit assistance ;Scores 29 or more must find professional medical units to get involved
Time frame: 1.5 months later
Psychological assessment
Taiwanese Depression Questionnaire (TDQ)Total score 0-54; score \>8 emotionally stable ;Score 9 \~ 14 Pay attention to emotional changes Score 15 \~ 18 pressure load reaches the critical point; Score 19-28 It is recommended to find a professional institution or medical unit assistance ;Scores 29 or more must find professional medical units to get involved
Time frame: 3 months later
Harris Benedict Equation
Total Daily Energy Expenditure
Time frame: baseline
Harris Benedict Equation
Total Daily Energy Expenditure
Time frame: 1.5 months later
Harris Benedict Equation
Total Daily Energy Expenditure
Time frame: 3 months later