Primary Lesion Treatment for Bone Metastases

N/ANot Yet RecruitingNCT05665790

Shanghai 6th People's Hospital400 enrolled

Overview

This study will carry out a prospective cohort study to study the effect of different primary leison treatment modes on disease control, quality of life, economic cost and survival period of patients with bone metastases from breast cancer and lung cancer by giving radiotherapy or palliative surgery or not giving local treatment for the primary lesion in patients with bone metastases from breast cancer or lung cancer

Study Type

INTERVENTIONAL

Allocation

NON_RANDOMIZED

Purpose

TREATMENT

Masking

NONE

Enrollment

400

Conditions

Bone Metastases

Interventions

radiotherapyRADIATION

radiotherapy

palliative surgeryPROCEDURE

palliative surgery

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: 1. HR positive breast cancer patients with bone metastasis or Non-small-cell lung cancer patients with bone metastasis； 2. Aged over 18; 3. ECOG：0-1； 4. Patients who benefit clinically(CR+PR) after 6 months of treatment. Exclusion Criteria: 1. The expected life span is less than 3 months; 2. Have serious cardiovascular and cerebrovascular diseases, blood coagulation dysfunction, and cannot tolerate surgery; 3. Allergies to narcotic drugs; 4. The patient refused the treatment decision of the integrated team.

Outcomes

Primary Outcomes

Disease control rate at 1 year

Disease control rate

Time frame: 1 year

Secondary Outcomes

Progression-Free Survival

Time frame: 1 year

Overall Survival

Time frame: 1 year

Data from ClinicalTrials.gov

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