DNI Values After Periodontal Treatment

Kahramanmaras Sutcu Imam University70 enrolled

Overview

The study included 70 systemically healthy individuals, as a test group of 35 patients with Stage 3, Grade A periodontitis and a control group of 35 individuals with no periodontal disease. Blood samples were taken for the examination of DNI, white blood cells (WBC), immature granulocytes (IG), procalcitonin, C-reactive protein (CRP), lymphocyte count and neutrophil count. For the patients with periodontitis, blood sample assays were repeated 3 months after NSPT.

The role of the Delta Neutrophil Index (DNI) in the pathogenesis and follow-up of periodontal disease has not been comprehensively documented. The study included 70 systemically healthy individuals, as a test group of 35 patients with Stage 3, Grade A periodontitis and a control group of 35 individuals with no periodontal disease. Blood samples were taken for the examination of DNI, white blood cells (WBC), immature granulocytes (IG), procalcitonin, C-reactive protein (CRP), lymphocyte count and neutrophil count. For the patients with periodontitis, blood sample assays were repeated 3 months after NSPT.

Study Type

INTERVENTIONAL

Allocation

Purpose

TREATMENT

Masking

NONE

Enrollment

Conditions

Periodontitis Periodontal Inflammation Inflammatory Response

Interventions

Only routine non-surgical periodontal treatment was applied to the patients.OTHER

Eligibility

Sex: ALLMin age: 18 YearsMax age: 65 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Patients diagnosed with periodontitis * Patients have more than 20 teeth in the mouth * Minimum age 18 * Maximum age 65 Exclusion Criteria: * Patients with any systemic disease * Active smokers * Pregnant or breastfeeding * Patients have used any antibiotic or anti-inflammatory drug in the last 6 months * Patients have received any periodontal treatment in the last 6 months.

Locations (1)

Kahramanmaraş Sütçü İmam University

Kahramanmaraş, Turkey (Türkiye)

Outcomes

Primary Outcomes

Changes in Delta Neutrophil Index values of periodontal treatment in patients with periodontitis.

We expect a decrease in the Delta Neutrophil Index values after non-surgical periodontal treatment.

Time frame: 12 weeks

Secondary Outcomes

Neutrophil-lymphocyte ratio (NLR) values after non-surgical periodontal treatment.

We expect a decrease in the neutrophil-lymphocyte ratio (NLR) values after non-surgical periodontal treatment.

Time frame: 12 weeks

Data from ClinicalTrials.gov

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