An AstraZeneca-sponsored observational, electronic healthcare record (EHR)-embedded retrospective cohort study to assess the real-world effectiveness of EVUSHELD against SARS-CoV-2 infection, COVID-19-related hospitalization, and other COVID-19 related outcomes in the total EUA-eligible patient population in the University of Pittsburgh Medical Center (UPMC) Health System.
This a Phase IV observational, secondary data study to assess the effectiveness of Evusheld in preventing COVID-19 infection and severe outcomes using the electronic medical records from the nationwide integrated health system. The study is designed as an AstraZeneca-sponsored observational, electronic healthcare record (EHR)-embedded retrospective cohort study to assess the real-world effectiveness of EVUSHELD against SARS-CoV-2 infection, COVID-19-related hospitalization, and other COVID-19 related outcomes in the total EUA-eligible patient population in UPMC health system
Study Type
OBSERVATIONAL
Enrollment
4,232
EVUSHELD (AZD 7442, Tixagévimab/Cilgavimab)
Research Site
Pittsburgh, Pennsylvania, United States
COVID-19 hospitalisation
To assess the effectiveness of EVUSHELD as PrEP against COVID-19 hospitalisation
Time frame: 6 months
All-cause mortality
To assess the effectiveness of EVUSHELD as PrEP against all-cause mortality
Time frame: 6 months
SARS-CoV-2 infection
To assess the effectiveness of EVUSHELD as PrEP against documented SARS-CoV-2 infection
Time frame: 6 & 12 months
Medically attended COVID-19
To assess the effectiveness of EVUSHELD as PrEP against medically attended COVID-19
Time frame: 6 & 12 months
Medically attended acute COVID-19
To assess the effectiveness of EVUSHELD as PrEP against medically attended acute COVID-19
Time frame: 6 & 12 months
COVID-19 hospitalisation
To assess the effectiveness of EVUSHELD as PrEP against COVID-19 hospitalisation
Time frame: 12 months
COVID-19 intensive care unit (ICU) admission
To assess the effectiveness of EVUSHELD as PrEP against COVID-19 intensive care unit (ICU) admission
Time frame: 6 & 12 months
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