AssesSment of Early-deteCtion basEd oN liquiD Biopsy in Biliary Tract Cancer (ASCEND-BTC)

Inclusion Criteria for Cancer Arm Participants: * Age 40-75 years at the day of consenting to the study. * Able to provide a written informed consent * Pathologically confirmed biliary tract cancers. * No prior or ongoing anti-cancer therapy (local or systematic) prior to study blood draw. Exclusion Criteria for Cancer Arm Participants: * Pregnancy or lactating women. * Recipients of organ transplant or prior non-autologous (allogeneic) bone marrow transplant or stem cell transplant. * Recipients of blood transfusion within 7 days prior to study blood draw. * Recipients of any anti-cancer therapy within 30 days prior to study blood draw, due to diseases other than cancers. * With other known malignant tumors or multiple primary tumors. Inclusion Criteria for Benign Arm Participants: * Age 40-75 years at the day of consenting to the study. * Able to provide a written informed consent. * Confirmed diagnosis of benign biliary tract diseases. * No prior radical treatment of the benign diseases prior to study blood draw. Exclusion Criteria for Benign Arm Participants: * Pregnancy or lactating women. * Recipients of organ transplant or prior non-autologous (allogeneic) bone marrow transplant or stem cell transplant. * Recipients of blood transfusion within 7 days prior to study blood draw. * Recipients of any anti-cancer therapy within 30 days prior to study blood draw, due to diseases other than cancers. * Confirmed diagnosis of malignancies or precancerous lesion. * A history of malignant tumors.