The goal of this study is to compare the blood pressure control ability with HPI, ClearSight, and conventional NIBP during neuraxial anesthesia in cesarean section. The main question it aims to answer is: Anesthesiologists can have a better control of blood pressure during cesarean section with HPI than with conventional NIBP. During the surgery, the participants will be monitored with standard monitor and HPI with ClearSight and will be randomly assigned to three groups, including HPI group, ClearSight group, and NIBP group. Anesthesiologists will treat intraoperative hypotension with different protocols according to the participants' allocation. Investigators will compare the time-weighted average mean arterial pressure \< 65mmHg with in three groups. Secondary outcomes includes the intraoperative hypotension rate, total duration of hypotension, the hypotension symptoms and signs of parturients.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
SINGLE
Enrollment
255
The Hypotension Prediction Index (HPI) is an algorithm based on the complex analysis of features in high-fidelity arterial pressure waveform recordings developed to observe subtle signs that could predict the onset of hypotension in surgical and intensive care unit patients. HPI is a unitless number that ranges from 1 to 100, and as the number increases, the likelihood of a hypotensive event (MAP \<65 mm Hg for more than 1 minute) occurring in the near future increases. In a validation study on HPI conducted in patients under general anesthesia, the algorithm, at its optimal value, predicted hypotension with both sensitivity and specificity of 86% 5 minutes before the event. Measurement of the arterial pressure waveforms using a finger cuff (ClearSight) is well established.
ClearSight is a non-invasive hemodynamic monitoring device using digital-cuff and volume-clamp technology to obtain a continuous arterial blood pressure waveform. Continuous finger blood pressure measurement is established by wrapping the cuff around the middle phalanx of a finger. The area under the waveform curve is analyzed using a unique algorithm that serves to calculate the arterial blood pressure, stroke volume (SV) and CO.
National Taiwan University Hospital
Taipei, Taiwan
RECRUITINGtime-weighted MAP below 65 mmHg
Time frame: through the surgery completion, an average of 1.5 hours
rates of parturients with intraoperative hypotension
hypotension is defined as MAP below 65 mmHg for more than 1 minute
Time frame: through the surgery completion, an average of 1.5 hours
total hypotension duration
hypotension is defined as MAP below 65 mmHg for more than 1 minute
Time frame: through the surgery completion, an average of 1.5 hours
area under curve of hypotension
hypotension is defined as MAP below 65 mmHg for more than 1 minute
Time frame: through the surgery completion, an average of 1.5 hours
total vasopressor dosage
average norepinephrine dosage used during the surgery
Time frame: through the surgery completion, an average of 1.5 hours
rate of hypotension related symptoms and sign of the parturients
symptoms and signs include nausea, vomiting, bradycardia, dizziness, and shivering
Time frame: through the surgery completion, an average of 1.5 hours
average regional cerebral oxygen saturation
Time frame: through the surgery completion, an average of 1.5 hours
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