Study objectives: 1. Describe the characteristics of discharged patients with schizophrenia achieving functional remission after drug discontinuation. 2. Establish a prediction model of patients with schizophrenia having good prognosis after drug discontinuation.
There are 2 clinically important and urgent questions to be explored in this study: 1. Who is more likely to benefit from guided drug reduction or discontinuation? How to design an individualized treatment plan which can balance the risk of relapse and side-effects from antipsychotics? 2. What are the predictors of functional remission in patients with schizophrenia after drug discontinuation? This will be the first related study to be conducted in China.
Study Type
OBSERVATIONAL
Enrollment
480
Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine
Shanghai, Shanghai Municipality, China
Functional remission dimension 1
World Health Organization Quality of Life abbreviated version（WHOQoL-BREF), score from 26 to 130. Higher score indicates better functional remission.
Time frame: Up to 28 weeks
Functional remission dimension 2
Functional Remission of General Schizophrenia Scale (FROGS), scale from 19 to 95. Higher score indicates better functional remission.
Time frame: Up to 28 weeks
Symptom assessment dimension 1
the Positive and Negative Syndrome Scale (PANSS), score from 30 to 210. High score indicates severe symptoms.
Time frame: Up to 28 weeks
Symptom assessment dimension 2
Clinical Global Impression (CGI), score from 1 to 7. High score indicates severe symptoms.
Time frame: Up to 28 weeks
This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.