Atopic dermatitis (AD) is a skin condition that may cause a rash and itching due to inflammation of the skin. This study will assess how effective upadacitinib is in treating AD. Upadacitinib is an approved drug for treating AD. Approximately 300 adolescent and adult participants who are prescribed upadacitinib by their physician in accordance with local label will be enrolled in France. Participants will receive upadacitinib as prescribed by their physician according to their routine clinical practice and local label. Participants will be followed up for approximately 24 months per participant and 30 days after last treatment dose for safety data collection. There is expected to be no additional burden for participants in this trial. Participants will attend regular visits during the study at a hospital or clinic according to their routine clinical practice.
Study Type
OBSERVATIONAL
Enrollment
300
Ch Saint Quentin /Id# 249270
Saint-Quentin, Aisne, France
CHU Clermont-Ferrand /ID# 248611
Clermont, Auvergne-Rhône-Alpes, France
Hôpital Européen Marseille /ID# 257643
Marseille, Bouches-du-Rhone, France
Hopital Saint Joseph /ID# 255537
Marseille, Bouches-du-Rhone, France
Hopital Ponchaillou /ID# 251225
Rennes, Brittany Region, France
Percentage of Participants achieving an absolute SCORing Atopic Dermatitis (SCORAD) of <25
SCORAD is a clinical tool used to assess the extent and severity of eczema (SCORing Atopic Dermatitis). The extent is assessed using the rule of 9 to calculate the affected area (A) as a percentage of the whole body (0-100%). The intensity part of the SCORAD (B) consists of 6 items: erythema, oedema/papulation, excoriations, lichenification, oozing/crusts and dryness, each graded on a scale from 0 (none) to 3 (severe), for a total score of 0 to 18. Subjective items (C) include daily pruritus and sleeplessness, each scored on a visual analogue scale (VAS) from 0 to 10 (total score 0-20). SCORAD is calculated as A/5 + 7B/2 + C, and ranges from 0 to 103 (worst).
Time frame: Month 4
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CHU Dijon /ID# 248984
Dijon, Cote-d Or, France
CH Georges Renon /ID# 248976
Niort, Deux-Sevres, France
CHU de Besancon - Jean Minjoz /ID# 248642
Besançon, Doubs, France
Hopitaux Drome Nord /ID# 248207
Romans-sur-Isère, Drome, France
CH Valence /ID# 250693
Valence, Drome, France
...and 49 more locations