Mechanically ventilated patients are at risk of developing ventilator-associated pneumonia (VAP). Invasive pulmonary aspergillosis (IPA), the diagnosis of which motivates the implementation of specific treatments, is one of the causes of VAP. The hypothesis of the study is that the incidence of IPA is 12.4%. For each patient presenting with a suspicion of VAP and requiring a bronchoalveolar lavage (BAL), the diagnosis of API will be evaluated by biological examinations performed on blood and BAL. Medical and surgical history as well as clinical and biological data will be collected for 28 days or until discharge from the ICU.
Study Type
OBSERVATIONAL
Enrollment
263
Direct examination and culture of BAL Galactomannan in serum and BAL Serum 1,3 beta D glucans Aspergillus PCR in BAL
Pôle de Réanimation Hôpital R. Salengro, CHU de Lille
Lille, France
Incidence of probable or proven IPA according to the Verweij criteria in patients with suspected VAP
Time frame: On the 1 day of inclusion
Incidence of IPA according to the Blot criteria
Time frame: On the 1 day of inclusion
Incidence of Aspergillus tracheobronchitis associated with IPA according to the Verweij criteria
Time frame: On the 1 day of inclusion
Incidence of IPA according to the Verweij criteria in the subgroup without risk factors.
Time frame: On the 1 day of inclusion
Mortality
Time frame: at 28 days
Length of stay in intensive care unit
Time frame: Until discharge from the ICU, an average 28 days
Duration of mechanical ventilation
Time frame: Until discharge from the ICU, an average 28 days
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