Primary research purpose: -Prospective study to screen post stroke patients with sarcopenia and evaluate its effect on recovery Secondary research purpose: * To determine the degree of sarcopenia and correlation with poor functional prognosis of stroke in the stroke patient group. * To determine the degree of sarcopenia and correlation with dixon MRI of thigh muscle * To evaluate surface EMG (SEMG)-based signals and correlation with sarcopenia * To determine the degree of sarcopenia and correlation with brain morphometric changes
Patients with first-ever stroke will be enrolled and assessed for sarcopenia. The evaluation parameters will include standard sarcopenia parameters and also SEMG-based signals and imaging studies.
Study Type
OBSERVATIONAL
Enrollment
83
Fu of diagnostic tests
The Catholic University of Korea
Bucheon-si, Gyeonggi-do, South Korea
St. Vincent's Hospital
Suwon, South Korea
Change of Modified Rankin Scale
Functional Disability -\> The scale runs from 0-6, running from perfect health without symptoms(0) to death(6).
Time frame: 6 months from the first onset of the stroke
Hand grip strength
Grip strength: Grip strength will be measured using a dynamometer
Time frame: within 4 weeks, 4 weeks, 8 weeks, 6 months from the first onset of the stroke
quadriceps muscle strength
Lower extremity strength assessment:change in isometric quadriceps muscle strength (kg) from initial evaluation to the final evaluation
Time frame: within 4 weeks, 4 weeks, 8 weeks, 6 months from the first onset of the stroke
Fugl-Meyer motor scale
Motor function assessment : Fugl-Meyer motor scale from initial evaluation to the final evaluation (Upper Extremity maximum score = 66; Lower Extremity maximum score = 34, Higher score means better outcome)
Time frame: within 4 weeks, 4 weeks, 8 weeks, 6 months from the first onset of the stroke
Functional Ambulation Category
Gait function assessment : Functional Ambulation Category from initial evaluation to the final evaluation (Minimum 0, Maximum 5; Higher score means better outcome)
Time frame: within 4 weeks, 4 weeks, 8 weeks, 6 months from the first onset of the stroke
Berg balance scale
Balance function: change in Berg balance scale from initial evaluation to the final evaluation (Minimum score 0, Maximum score 56, Higher score means better outcome)
Time frame: within 4 weeks, 4 weeks, 8 weeks, 6 months from the first onset of the stroke
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Brain MRI
Brain atrophy : change in the Global cortical atrophy scale(0-3) of the cerebral cortex from initial evaluation to the final evaluation
Time frame: within 4 weeks and 6 months from the first onset of the stroke
Thigh Dixon MRI
Muscle quality : muscle circumference measured by the thigh MRI from initial evaluation to the final evaluation
Time frame: within 4 weeks and 6 months from the first onset of the stroke
Muscle ultrasonography
muscle thickness(cm) measured by the ultrasound of the quadriceps muscle from initial evaluation to the final evaluation
Time frame: within 4 weeks and 6 months from the first onset of the stroke
serum biomarkers for sarcopenia
BNDF, IL-6
Time frame: within 4 weeks from the first onset of the stroke
Digitalized SEMG signals
state of the art EMG signals will be collected to assess muscle quality changes after stroke
Time frame: within 4 weeks, 4 weeks, 8 weeks, 6 months from the first onset of the stroke