The overarching hypothesis of this proposal is that IL-5 acts on multiple sinus tissue cell types, including plasma cells and epithelial cells, to promote immune dysregulation, and that inhibition of IL-5 affects several relevant effector pathways that lead to clinical benefit.
Further characterization of the role of IL-5Rα expression and function on human plasma cells will determine whether inhibiting IL-5 signaling on these cells offers therapeutic promise in other diseases related to plasma cell proliferation. Further characterization of human upper airway epithelial cell IL-5Rα expression and function will determine whether or not inhibiting IL-5 signaling on these cells offers therapeutic promise in other diseases related to epithelial dysfunction. IL-5Rα expression has been identified on several relevant sinus tissue effector cells, including on nasal polyp plasma cells and epithelial cells, and the aim of this study is to further the field by determining the consequences of IL-5 signaling on those cells.
Study Type
OBSERVATIONAL
Enrollment
30
No intervention.
Brigham and Women's Hospital
Boston, Massachusetts, United States
Number of Participants With Nasal Polyp Plasma Cell Transcriptome
We will determine the number of participants from whom a transcriptional profile of nasal polyp plasma cells is analyzable from bulk RNA sequencing of sorted nasal polyp plasma cells.
Time frame: At baseline
Number of Participants With Functional Readouts of IL-5Ra on Nasal Polyp Plasma Cells.
We will determine the number of participants from whom a readout of IL-5Ra is analyzable from the plasma cells in their nasal tissue
Time frame: At baseline
Number of Patients for Whom IL-5Ra Signaling on Nasal Epithelial Cells Can be Analyzed
We will determine the number of participants from whom IL-5-elicited signaling on their nasal epithelial tissue can be analyzed.
Time frame: At baseline
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