Although significant advances in screening and treatment , cervical cancer is the fifth most common female cancer in Europe. Major prognostic factors for oncological outcome are used to categorise patients at high, intermediate and low risk groups and to define the type of radical hysterectomy according "Querleu-Morrow classification". The goal of this prospective observational study is to evaluate the association between several inflammatory markers and risk groups according European guidelines in women with cervical cancer Human Papillomavirus (HPV)-associated, in order to optimize the treatment.
European guidelines have proposed a risk stratification of patients basing on oncological risk. The type of radical hysterectomy (extent of parametrial resection and type according Querleu-Morrow classification) should be based upon the presence of prognostic risk factors.Major prognostic factors for oncological outcome as tumour size, maximum stromal invasion, Lymphovascular space invasion (LVSI) are used to categorise patients at high, intermediate and low risk for treatment failure. The investigators want to identify additional parameters to better define risk profiles. Systemic inflammation indices such as neutrophil to lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR) and lymphocyte to monocyte ratio (LMR) have shown prognostic value in solid tumors and several inflammatory conditions. Therefore, the primary endpoint of the present study is to assess the role of systemic inflammatory indices and risk groups stratification in patients with early cervical cancer.
Study Type
OBSERVATIONAL
Enrollment
128
Blood chemistry tests: neutrophil;lymphocyte; monocyte; platelet counts
histopathology findings
Università degli Studi della Campania Luigi Vanvitelli
Naples, Italy
RECRUITINGGrading
Anatomic pathology report of cell anaplasia in the sampled tumor
Time frame: 30 days after surgery
Staging
Anatomic pathology report of extent to which the cancer has spread
Time frame: 30 days after surgery
Lymphovascular space invasion
Prognostic factor in cervical cancer
Time frame: 30 days after surgery
Histotype
Anatomic pathology report of tissue types of cancer
Time frame: 30 days after surgery
Tumor size
centimeters
Time frame: 30 days after surgery
Neutrophil-Lymphocyte Ratio (NLR)
an absolute value obtained from the ratio of neutrophils to lymphocytes
Time frame: 1 day previous surgery
Platelet-lymphocyte ratio(PLR)
an absolute value obtained from the ratio of platelets to lymphocytes
Time frame: 1 day previous surgery
Lymphocyte-monocyte Ratio (LMR)
an absolute value obtained from the ratio of lymphocytes to monocytes
Time frame: 1 day previous surgery
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