A Study of Brensocatib Following a Single Oral Administration in Participants With or Without Renal Impairment

Inclusion Criteria: * Has a body mass index (BMI) 18 to 35 kilograms per square meter (kg/m\^2), inclusive, and a body weight of ≥50 kg at Screening. Inclusion Criteria (for Participants With Renal Impairment): * Mild, moderate, or severe renal impairment as determined by estimated glomerular filtration rate (eGFR) and calculated using the Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) formula. * Renal insufficiency or other related concomitant medical conditions (e.g., hypertension, anemia) has remained stable for at least 3 months before study drug dosing. Inclusion Criteria for Healthy Participants: * Normal renal function as determined by eGFR and calculated using the CKD-EDI formula, or by 24-hour urine creatinine clearance (CLcr) corrected for body size. * In good general health, as determined by medical history, clinical laboratory assessments, vital sign measurements, 12-lead electrocardiogram (ECG) results, and physical examination findings. Exclusion Criteria: * Positive test result for human immunodeficiency virus types 1 or 2 antibodies, hepatitis C virus antibodies, or hepatitis B surface antigen or hepatitis B core antibodies. * History of relevant drug and/or food allergies (i.e., allergy to brensocatib or any excipients, or any significant food allergy). * The participant has received study drug in another investigational study within 30 days of Screening. Exclusion Criteria (for Participants With Renal Impairment): * Has nephrotic syndrome, defined as urine dipstick 4+ for protein and plasma albumin \<3.0 grams per deciliter (g/dL), and then confirmed if proteinuria \>5 g/day. * Has an extrarenal cause of renal impairment (e.g., rapidly growing, space occupying lesions, adrenal enlargement). * Has a functioning renal transplant (participant may be included in the study if he or she had a failed renal transplant and is not taking immunosuppressants). * Has a hemoglobin value less than 8.5 g/dL. * Has Type 1 or Type 2 diabetes mellitus. Exclusion Criteria (for Healthy Participants): * Has used any prescription (excluding hormonal birth control, hormone replacement therapy, nonsteroidal anti-inflammatory drugs, or acetaminophen) or over-the-counter medications, including herbal or nutritional supplements, within 14 days before study drug dosing and throughout the study. Note: Other inclusion/exclusion criteria may apply.