In this study, we aimed to (1) compare cumulative incidences of synchronous and metachronous colorectal neoplasia as well as mortality following AN in CD and UC patients who underwent proctocolectomy, (sub)total colectomy, partial colectomy or endoscopic resection, and (2) to determine factors associated with AN treatment choice.
In this retrospective multicenter cohort study, using PALGA (the Dutch nationwide pathology databank), partial colectomy yielded a similar metachronous neoplasia risk compared to (sub)total colectomy after treatment of advanced neoplasia in inflammatory bowel disease. High metachronous neoplasia rates after endoscopic resection underline the importance of strict subsequent endoscopic surveillance.
Study Type
OBSERVATIONAL
Enrollment
189
endoscopic or surgical (partial, (sub)total, proctocolectomy) resection
Radboudumc
Nijmegen, Gelderland, Netherlands
Synchronous
defined as co-existence of two or more neoplastic colorectal lesions detected in the initial resection specimen or up to 6 months after treatment of the index lesion, categorized in (a) any neoplasia (independent of grade) and (b) only AN
Time frame: up to 6 months
Metachronous (advanced) neoplasia
defined as colorectal neoplasia detected \>6 months after treatment of index AN, categorized in (a) any neoplasia (independent of grade) and (b) only AN, including the impact of IBD type
Time frame: up to 30 years
All-cause mortality
All-cause mortality
Time frame: up to 30 years
Associations with treatment choice
Clinical and disease characteristics associated with AN treatment choice
Time frame: up to 30 years
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