In this study, we plan to systematically analyze the motion of organs and tissues in the abdomen, to understand the physical mechanisms of three-dimensional (3D) motion and interactions of abdominal organs and tissues. This work will allow us to learn how to mathematically model and predict abdominal organ motion.
Specifically, we plan to conduct this study in 3 steps, in an order of increasing complexity, starting with the (intra-fractional) respiratory only motion, then adding intra-fractional GI motility motion, and finally the inter-fractional anatomical variations (adding food intakes and fecal excretion). The research methods described will allow the study team to develop the ability to estimate the motion of both tumor target and critical organs given the patient's MRI, CBCT or x-ray fluoroscopy images on the day of radiation treatment.
Study Type
INTERVENTIONAL
Allocation
NA
Purpose
OTHER
Masking
NONE
Enrollment
5
collection of MRI scans for mathematical model development
Duke University Medical Center
Durham, North Carolina, United States
abdominal respiratory motion as measured by MRI
Time frame: baseline
gastrointestinal motility motion as measured by MRI
Time frame: baseline
inter-fractional motion as measured by MRI
inter-fractional motion is defined as the change in motion of organs and tissues between different image examinations on different days
Time frame: baseline, up to 6 months
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