Urinary Tract Infection in Patients With Chronic Kidney Disease

Alexandria University250 enrolled

Overview

This study aims to investigate the etiology and associated risk factors for UTI in Egyptian chronic kidney disease patients. In addition, to identify the isolated micro-organisms and their sensitivity patterns for better anticipation of treatment regimen.

Chronic kidney disease (CKD) patients are at higher risk of urinary tract infections (UTI), as CKD is a state of chronic inflammation, metabolic disturbance and impaired immunocompetence. Moreover, patient with CKD are usually of advanced age and suffer from other comorbidities such as diabetes, hypertension, obesity, and cardiovascular diseases, which also add to their risk of infection. UTI comprises heterogeneous conditions ranging from mild cystitis, easily treated with oral antibiotics, to life-threatening sepsis and multiple organ failure. There is scarce information about risk factors of recurrence of UTI and infection with multidrug-resistant organisms in the Egyptian population.

Study Type

OBSERVATIONAL

Enrollment

250

Conditions

Urinary Tract Infections Chronic Kidney Diseases

Interventions

Patients with urinary tract infection and chronic kidney diseaseOTHER

The data that will be collected from the electronic patient records at the clinics through a google form will include sociodemographic (age, sex, weight and occupation), comorbidities (e.g., HTN, DM), medications used, renal functions (serum creatinine, and CKD stage calculated by 2021 CKD-EPI creatinine equation), and in case of positive urine culture (type of microorganism and antibiogram).

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: 1. Males and non-pregnant females aged ≥ 18 years old 2. Patients with CKD stages (G1 to G4) 3. Patients diagnosed with UTI due to urine culture Exclusion Criteria: 1. Non-CKD patients 2. pregnant females 3. CKD patients on immunosuppressant agents 4. ESRD patients on hemodialysis 5. Patients with structural abnormalities which make them liable to frequent UTI

Locations (1)

Faculty of Medicine, Alexandria University

Alexandria, Egypt

Outcomes

Primary Outcomes

prevalence of UTI in CKD patients

percentage of UTI in CKD patients

Time frame: records will be retrospectively screened from January 2019 till September 2022

isolated microorganisms causing UTI in CKD patients

isolated microorganisms in cultures causing UTI in CKD patients

Time frame: records will be retrospectively screened from January 2019 till September 2022

Secondary Outcomes

sensitivity pattern of urine cultures in CKD

describe sensitivity pattern of urine cultures in CKD

Time frame: records will be retrospectively screened from January 2019 till September 2022

Data from ClinicalTrials.gov

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