Effects of a Colon-delivered Multivitamin Supplement on Brain Functioning, Immunometabolic- and Intestinal Markers in Ageing

Inclusion Criteria: * Written informed consent * Age between 60-75 years (at pre-screening) * Fluency in Dutch (speaking, reading and writing) * Score ≥2 points on the risk factor scale below based on self report: * BMI≥25 (1 point) * Physical inactivity (according to WHO guidelines) (1 point) * Hypertension (1 point) * Hypertension without medication (1 point) * Hypercholesterolemia (1 point) * Diabetes type II (1 point) * Mild cardiovascular disease (1 point) Exclusion Criteria: * Food allergies or other issues with the vitamins included in the supplement * Concurrent participation in other intervention trials * Clinical diagnosis of ≥1 of the following: * Stroke; * Neurological disease(s) (e.g. MCI, dementia, MS, Parkinson's, epilepsy); * Current malignant disease(s), with or without treatment; * Current psychiatric disorder(s) (e.g. depression, psychosis, bipolar episodes, eating disorder); * Symptomatic cardiovascular disease (e.g. stroke, angina pectoris, heart failure, myocardial infarction); * Revascularisation surgery in the last 12 months at pre-screening; * Gastrointestinal diseases (i.e., diarrhoea, Crohn's disease, ulcerative colitis, diverticulosis, stomach or duodenal ulcers) or having a history of gastrointestinal surgical events (e.g. stoma) that may influence the results of the study, as determined by the study team; * Visual impairment (e.g. blindness); * Hearing or communicative impairment. * Use of antibiotics within the previous 3 months before the study start. * Use of protonpump inhibitors within the study period (esomeprazole, lansoprazole, omeprazole, pantoprazole, rabeprazole) * Not willing to refrain from taking other supplements (containing vitamin B2, B3, B6, B9, or C, prebiotic, or probiotic) that can interfere with the study outcomes, from at least 2 weeks before start of the intervention till the end of the intervention period. * Answering "Yes" on ≥1 of the Donders Institute MRI safety screening protocol questions (see the 8 questions below): 1. Are there metal objects located in your upper body? Exception: tooth-fillings and/or dental crowns. 2. Are there metal splinters in your body, in particular within the eyes? For example: through labour work in the metal industry. 3. Are there jewellery items or piercings that you are unable to take off? 4. Have you had a brain surgery in the past? 5. Are there active implants present? For example: pacemaker, neurostimulator, insulin pump, hearing aid (that is unable to be removed). 6. Are there any medical plasters or patches that you can't or may not take off? For example: nicotine patch. 7. Do you suffer from epilepsy? 8. Do you suffer from claustrophobia? * Cognitive impairment as determined by Telephone Interview for Cognitive Status (TICS-M1), performed during pre-screening before inclusion and defined as a score \<23.