Iron Deficiency and TTG Normalization

Meir Medical Center118 enrolled

Overview

The investigators conducted a retrospective, observational cohort study which enrolled CD subjects aged 2-18y, diagnosed between Jan 2016 and Dec 2020. Demographic and laboratory data were collected at diagnosis and 1y after adherence to GFD. ID was determined according to hemoglobin and ferritin levels. The investigators compared CD subjects with and without ID at CD diagnosis in relation to TTG normalization at 1y.

Study Type

OBSERVATIONAL

Enrollment

118

Conditions

Celiac Disease in Children

Interventions

Gluten free dietOTHER

All subjects initiated a gluten free diet as mandated by their diagnosis of Celiac disease, regardless of the study

Eligibility

Sex: ALLMin age: 2 YearsMax age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Children (male and female) diagnosed with CD * Age 2-18y Exclusion Criteria: * Total IgA deficiency * Anemia due to other causes - anyone with anemia and normal or elevated ferritin levels (e.g. thalassemia, spherocytosis) * Other chronic conditions increasing the risk of anemia or falsely elevated ferritin (e.g. inflammatory bowel disease, chronic kidney disease, infection)

Locations (1)

Meir medical center

Kfar Saba, Israel

Outcomes

Primary Outcomes

TTG normalization

normalization of tissue transglutaminase antibody

Time frame: 1 year from gluten free diet initiation

Data from ClinicalTrials.gov

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