The present study will utilize esophageal manometry to measure the presence and magnitude of persistent patient effort during lung protective ventilation, allowing identification and mitigation of occult lung stress.
Study Type
INTERVENTIONAL
Allocation
NA
Purpose
OTHER
Masking
NONE
Newly designed external monitor that will capture esophageal pressure from a proprietary nasogastric tube combined with simultaneous pressure, flow, and volume measurements from the ventilator tubing.
Tisch Hospital
New York, New York, United States
Transpulmonary Driving Pressure
Transpulmonary driving pressure is the pressure difference between the airway opening and pleural surface. It represents lung stress and is higher with increased spontaneous respiration and work of breathing.
Time frame: Up to Hour 2 (Day 1)
Driving Pressure
Driving pressure is defined as plateau pressure minus positive end-expiratory pressure (PEEP). Driving pressure during mechanical ventilation is directly related to stress forces in the lung.
Time frame: Up to Hour 2 (Day 1)
Work of Breathing (WOB)
WOB is the amount of energy or oxygen (O2) consumption needed by the respiratory muscles to produce enough ventilation and respiration to meet the metabolic demands of the body.
Time frame: Up to Hour 2 (Day 1)
Pressure-Time Product (PTP)
PTP is the product of the average inspiratory pressure (starting from the onset of effort) and the duration of inspiration. The PTP was developed to account for energy expenditures during the dynamic and isometric phases of respiration.
Time frame: Up to Hour 2 (Day 1)
Lung Compliance (C, l)
Lung compliance is calculated as the tidal volume divided by the difference of transpulmonary pressure at end inspiration minus transpulmonary pressure at PEEP: (C, l) = tidal volume/(transpulmonary pressure at end inspiration - transpulmonary pressure at PEEP). Expressed in (ml/cmH2O).
Time frame: Up to Hour 2 (Day 1)
Chest Wall Compliance (C, cw)
Chest wall compliance is calculated as the tidal volume divided by the difference of esophageal pressure at end inspiration minus esophageal pressure at PEEP: (C, cw) = tidal volume/(esophageal pressure at end inspiration - esophageal pressure at PEEP). Expressed in (ml/cmH2O).
This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.
Time frame: Up to Hour 2 (Day 1)
Respiratory System Compliance (C, rs)
Respiratory System Compliance is calculated as the tidal volume divided by the difference of the airway pressure at end inspiration minus airway pressure at PEEP: (C, rs) = tidal volume/(airway pressure at end inspiration - airway pressure at PEEP). Expressed in (ml/cmH2O).
Time frame: Up to Hour 2 (Day 1)
Oxygen Saturation
Oxygen saturation is the fraction of oxygen-saturated hemoglobin relative to total hemoglobin in the blood.
Time frame: Up to Hour 2 (Day 1)
PaO2/FiO2 (P/F) Ratio
The P/F ratio is the arterial partial pressure of oxygen (PaO2) divided by the inspired oxygen concentration (FiO2).
Time frame: Up to Hour 2 (Day 1)