Psilocybin for Major Depressive Disorder

Inclusion Criteria: * Currently meeting DSM-V Criteria for a Major Depressive Episode of at least mild-moderate severity * Aged 18-85 * Ability and willingness to attend study visits and complete study assessments Exclusion Criteria: * Presence of medical conditions at screening that may affect the safe administration of psilocybin (including, but not limited to: AST/ALT \> 150, QTc \> 450ms, MELD \> 9) * Depression deemed secondary to a severe medical condition * Recent use of any classical psychedelic drug or MDMA * Recent use of any interventional psychiatric treatment (including: ECT, ketamine, esketamine, TMS) * Intention to begin any new treatment for depression prior to primary outcome determination * Use of any excluded medication * Active substance use disorder * Presence of any psychiatric condition that may interfere with the safe administration of psilocybin * Active suicidal ideation