This study assesses the glycemic responses to several nutritional products.
During a study visit fasted subjects will consume one serving of the reference product or of the test products. Venous blood samples will be taken at baseline and at several time-points over a 6-hr period.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
DOUBLE
Enrollment
18
Fasted intake of First concept product (randomised)
Fasted intake Second concept product (randomised)
Fasted intake of Reference product (randomised)
EB UtrechtResearch BV
Utrecht, Netherlands
Decline in glucose level after reaching peak (Cmax)
The decline in glucose (mmol/hour) after reaching peak glucose levels (Cmax) until reaching baseline (t = -5) blood glucose levels or, in case baseline blood glucose levels are not reached, the lowest observed blood glucose level.
Time frame: 6 hours
Incremental Area Under the Curve (iAUC) for glucose
Incremental Area Under the Curve (iAUC) for glucose (mmol/L/hrs)
Time frame: 6 hours
Incremental Area Under the Curve (iAUC) for insulin
Incremental Area Under the Curve (iAUC) for insulin (pmol/L/hrs)
Time frame: 6 hours
Incremental Area Under the Curve (iAUC) for paracetamol
Incremental Area Under the Curve (iAUC) for paracetamol (pmol/L/hrs)
Time frame: 6 hours
Incremental peak levels (iCmax) of glucose
Incremental peak levels (iCmax) of glucose (mmol/L)
Time frame: 6 hours
Incremental peak levels (iCmax) of insulin
Incremental peak levels (iCmax) of insulin (pmol/L)
Time frame: 6 hours
Incremental peak levels (iCmax) of paracetamol
Incremental peak levels (iCmax) of paracetamol (mg/L)
Time frame: 6 hours
Time to peak levels (Tmax) of glucose
Time to peak levels (Tmax) of glucose (min)
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Time frame: 6 hours
Time to peak levels (Tmax) of insulin
Time to peak levels (Tmax) of insulin (min)
Time frame: 6 hours
Time to peak levels (Tmax) of paracetamol
Time to peak levels (Tmax) of paracetamol (min)
Time frame: 6 hours