We will get the impact of duloxetine versus imipramine on therapeutic efficacy in women with SUI.
Background/Purpose: Pharmacologic treatments for female stress urinary incontinence (SUI) include duloxetine and imipramine. Duloxetine and Imipramine has been reported to have clinical significant therapeutic efficacy on female SUI and overactive bladder syndrome. However, there was no randomized controlled study to compare duloxetine and imipramine for the treatment of female SUI. Patients and Methods: We will perform a prospective randomized controlled study to recruit 90 female SUI patients at the Obstetrics \& Gynecology outpatient clinic of Far Eastern Memorial Hospital. All SUI female patients will be asked to complete ICIQ-UI, USS, OABSS, and bladder diary before and after 4 weeks' duloxetine versus imipramine treatment.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Enrollment
90
Duloxetine 30 mg per day
Imipramine 25 mg per day
Department of Obstetrics and Gynecology, Far Eastern Memorial Hospital
Banqiao District, New Taipei, Taiwan
RECRUITINGImprovement of stress urinary incontinence
Urinary Incontinence Questionnaire (by ICIQ-UI short form)
Time frame: 4 weeks
Improvement of urgency symptoms
Urgency severity scale
Time frame: 4 weeks
Improvement of overactive bladder symptoms
Overactive bladder symptom score
Time frame: 4 weeks
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