Longitudinal Study on the Influence of Iodine Nutrition Status on Thyroid Function of Childbearing Age Women During Pregnancy and 6 Weeks Postpartum

Beijing Friendship Hospital2,100 enrolled

Overview

The goal of this observational study is to provide a reference for formulating individual appropriate iodine intake programs for women during pregnancy and postpartum and improving the monitoring and evaluation system of maternal iodine nutrition status. The main questions it aims to answer are: * To analyse the longitudinal changes of urinary iodine, urinary iodine/creatinine ratio, thyroid function and related factors in different periods of early, middle, late pregnancy and 6 weeks postpartum in Beijing area. * To explore the relationship between iodine nutrition status and the changes of thyroid function and to further clarify the effect of iodine nutrition status on thyroid function of women of childbearing age during pregnancy and postpartum in combination with dietary intake of iodine questionnaire. Participants will be detected there thyroid function, the level of median urinary iodine and urinary iodine/creatinine. Researchers will compare healthy women of childbearing age served as the control group in the same period.

Study Type

OBSERVATIONAL

Enrollment

2,100

Conditions

Thyroid Function Iodine Nutrition Status

Interventions

Eligibility

Sex: FEMALEHealthy volunteers:

Medical Language ↔ Plain English

8-12 weeks healthy maternal: Inclusion Criteria: * primigravida * no chronic hypertension, thromboembolic disease, severe gastrointestinal, cardiopulmonary and liver diseases before pregnancy * no systemic lupus erythematosus, rheumatic diseases and other connective tissue diseases or immune diseases before pregnancy * no adrenocortical hyperplasia, pituitary endocrine diseases and other diseases before pregnancy Exclusion Criteria: * multiple pregnancies and multigravida * a history of type I or type II diabetes before pregnancy * a clear history of thyroid diseases before pregnancy * taking drugs that affect thyroid function and/or blood sugar before or during early pregnancy Healthy women of childbearing age: Inclusion Criteria: * 20-40 years old * no chronic hypertension, thromboembolic disease, severe gastrointestinal, cardiopulmonary and liver diseases * no systemic lupus erythematosus, rheumatic diseases and other connective tissue diseases or immune diseases * no adrenocortical hyperplasia, pituitary endocrine diseases and other diseases Exclusion Criteria: * a history of type I or type II diabetes * a clear history of thyroid diseases * taking drugs that affect thyroid function and/or blood sugar

Outcomes

Primary Outcomes

Data of pregnant women in the early trimester of pregnancy

detect the level of serum TSH, FT4, TPOAb, TGAb and the level of median urinary iodine and urinary iodine/creatinine

Time frame: Any day between weeks 8 and 12 of gestation

Data of pregnant women in the middle trimester of pregnancy

detect the level of serum TSH, FT4, TPOAb, TGAb and the level of median urinary

Time frame: Any day between weeks 24 and 28 of gestation

Data of pregnant women in the third trimester of pregnancy

detect the level of serum TSH, FT4, TPOAb, TGAb and the level of median urinary

Time frame: Any day between weeks 36 of gestation to the day before parturition

Data of postpartum women

detect the level of serum TSH, FT4, TPOAb, TGAb and the level of median urinary

Time frame: 6 weeks after parturition

Longitudinal Study on the Influence of Iodine Nutrition Status on Thyroid Function of Childbearing Age Women During Pregnancy and 6 Weeks Postpartum

Overview

Conditions

Interventions

Eligibility

Locations (1)

Outcomes

Primary Outcomes

Central Contacts