The present study aims at verifying the mutual effects between intracranial large artery atherosclerosis and cerebral small vessel disease on disease progression and prognosis by magnetic resonance imaging, and providing biomarkers for the early prevention and treatment of cerebrovascular disease.
Cerebrovascular disease is the most common cause of death worldwide. There is a close link in structure and function between the intracranial large arteries and cerebral small vessels. Moreover, growing evidences have demonstrated that large artery atherosclerosis often coexists with small vessel disease, which may deteriorate the clinical outcomes of stroke and dementia. The mutual feedback mechanism between them is not fully understood. The present study focuses on the mechanism of mutual feedback between large artery atherosclerosis and cerebral small vessel disease by using magnetic resonance imaging. The study may provide biomarkers for the early prevention and treatment of cerebrovascular disease.
Study Type
OBSERVATIONAL
Enrollment
300
Imaging diagnostics mainly based on Magnetic resonance imaging.
Chinese PLA General Hospital
Beijing, Beijing Municipality, China
RECRUITINGProgression in total cerebral small vessel disease burden
Total cerebral small vessel disease burden is assessed according to a sum of scores of white matter hyperintensity, cerebral microbleeds, lacunes and enlarged perivasular spaces on magnetic resonance imaging sequences.
Time frame: 1-3 YEARS
Frequency of stroke recurrence
The percentage of symptomatic participants who suffer from stroke recurrence after enrollment in the territory of the targeted stenotic vessel.
Time frame: 1-3 YEARS
Frequency of stroke of asymptomatic participants
The percentage of asymptomatic participants who suffer from stroke after enrollment in the territory of the targeted stenotic vessel.
Time frame: 1-3 YEARS
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