Structural and Functional Grey and White Matter Changes in Patients With Pain Disorders

Inclusion Criteria: 1. Patients with thalamic central post-stroke pain (CPSP) : Patients fulfilling all of the following inclusion criteria are eligible for the study: * Informed Consent as documented by signature (Appendix Informed Consent Form) * History of thalamic stroke (infarction or bleed) * Diagnosis of definite central-post stroke pain (according to the criteria proposed by Klit et al, 2009) * No other chronic pain condition * Age: ≥18 years old 2. Patients with thalamic stroke without CPSP: Patients fulfilling all of the following inclusion criteria are eligible for the study: * Informed Consent as documented by signature (Appendix Informed Consent Form) * History of thalamic stroke (infarction or bleed), at least 2 years ago * No chronic pain condition (neither CPSP or other pain condition) * Age ≥18 years old 3. Patients with migraine (other pain condition): Patients fulfilling all of the following inclusion criteria are eligible for the study: * Informed Consent as documented by signature (Appendix Informed Consent Form) * History of highly frequent (≥8 monthly migraine days) or chronic migraine (≥15 monthly migraine days). * No history of stroke * Age ≥18 years old 4. Healthy controls: Participants fulfilling all of the following inclusion criteria are eligible for the study: * Informed Consent as documented by signature (Appendix Informed Consent Form) * No history of stroke * No chronic pain condition * Age: ≥18 years old Exclusion Criteria: * History of severe neurological, internistic or psychiatric disease * MRI related exclusion criteria: * paramagnetic and/or superparamagnetic foreign objects in the body (especially when located close to the brain) * Pacemaker * Claustrophobia * Pregnancy