IV and Intrathecal Ketamine in Cesarean Section

Assiut University60 enrolled

Overview

In the current study, the investigators will compare the effects of low-dose intravenous (i.v.) ketamine versus intrathecal Ketamine added to spinal anesthesia on the time to first request for analgesia and maternal pain scores and overall satisfaction in patients undergoing cesarean section.

Study Type

INTERVENTIONAL

Allocation

Purpose

PREVENTION

Masking

TRIPLE

Enrollment

Conditions

Cesarean Section Analgesia

Interventions

Intrathecal ketamineDRUG

Patients will receive intrathecal Ketamine 0.1mg/kg added to bupivacaine and morphine

Intravenous ketamineDRUG

Patients will receive IV Ketamine 0.25mg/kg after spinal

Eligibility

Sex: FEMALEMin age: 18 YearsMax age: 45 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion criteria: • Pregnant undergoing elective cesarean section Exclusion Criteria * Significant coexisting diseases (pregnancy-induced hypertension or diabetes) * body mass index ≥40kg/m2, height \<150cm * Current use of pain medication including opioids * history of substance abuse or hallucinations, cardiovascular disease, diabetes, multiple gestations * chronic pain was excluded. * contraindications to spinal anaesthesia, * severely compromised fetus requiring general anesthesia and those patients who received labor analgesia

Locations (1)

Assiut university

Asyut, Egypt

Outcomes

Primary Outcomes

Time to the first analgesic request

Time frame: First Postoperative day

Secondary Outcomes

Postoperative pain scores NRS at rest and on movement; (2, 4, 6, 12, and 24 hours) postoperative

Time frame: first postoperative day

Data from ClinicalTrials.gov

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