The elderly patients over 65 years old with breast cancer have concomitant diseases, poor tolerance to conventional treatment, and the specific prognosis of breast cancer is relatively good. Previous studies on breast cancer have almost excluded elderly breast cancer patients, and conventional treatment schemes cannot meet the clinical diagnosis and treatment needs of elderly breast cancer patients. The establishment of a prognosis model for elderly breast cancer patients can provide personalized treatment programs. This is important for prolonging the survival time of patients and improving the quality of life. This project plans to observe the relationship between prognosis and pathological staging, molecular typing, and concomitant diseases of elderly breast cancer patients in combination with immune genes, and establish a prognosis model of elderly breast cancer and verify it. This project is expected to establish a new prognostic model for elderly breast cancer patients, accurately judge the prognosis of patients, and provide a new basis for hierarchical and personalized treatment of elderly breast cancer.
Study Type
OBSERVATIONAL
Enrollment
1,000
operation methods: breast-conserving surgery, mastectomy, axillary lymph node dissection, sentinal lymphnodes biopsy; chemotherapy regimens: AC, TC, AC-T/P, TCrb, TAC, capecitabine; ovarian protection:GnRHa; endocrine therapy: Aromatase inhibitor, TAM, Fulvestrant, CDK4/6 inhibitors; target therapy: trastuzumab,patuzumab, Pyrotinib.
Bisphosphonate
Peking Union Medical College Hospital
Beijing, China
RECRUITING5-y DFS
5-years of disease free survival
Time frame: 5 year
5-y BCSS
5-year of breast cancer-specific survival
Time frame: 5 year
5-y OS
5-year overall survival
Time frame: 5 year
10-y DFS
10-years of disease free survival
Time frame: 10 year
10-y BCSS
10-year of breast cancer-specific survival
Time frame: 10 year
10-y OS
10-year overall survival
Time frame: 10 year
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