Relation Between MicroRNA 203 and 210 and Sparing the Laparoscopic Examination in Cases of Unexplained Infertility

Benha University100 enrolled

Overview

The study targets to evaluate the role of estimation of plasma expression levels of gene of microRNAs 203 and 210 in helping to diagnose and grade endometriosis. The study included women with unexplained infertility and clinical picture suggestive of presence of endometriosis were divided randomly into two groups: Control and study groups. All patients underwent exploratory laparotomy for diagnosis and grading of endometriosis if present. Patients of study group gave blood samples for estimation of plasma expression levels of microRNA 203 and 210 using qRT-PCR procedure.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

DIAGNOSTIC

Masking

SINGLE

Enrollment

100

Conditions

Infertility Unexplained Endometriosis

Interventions

Laparoscopic Exploration to diagnose \& grade endometriosis

Estimation of Plasma Expression level of MICRO RNA 203 & 210DIAGNOSTIC_TEST

estimation of Plasma Expression level for Gene"Micro RNA "203 \& 210" by qRT-PCR

Eligibility

Sex: FEMALEMin age: 30 YearsMax age: 45 Years

Medical Language ↔ Plain English

Inclusion Criteria: * 30-45 years old * Unexplained infertility Exclusion Criteria: * Presence of other causes of infertility, * age out of the predetermined range, * the presence of immune disorders, * maintenance on immunosuppressive drugs

Locations (1)

Banha University

Banhā, El- Qalyobia, Egypt

Outcomes

Primary Outcomes

grading of endometriosis

The diagnostic performance of estimated plasma levels of microRNA for diagnosis and grading endometriosis

Time frame: 8 months

Data from ClinicalTrials.gov

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