This goal of this clinical trial is to study the efficacy of collagen supplement on skin moisture and elasticity in middle-aged women of 30-50 years old. Participants will be assigned two products with and without collagen supplement and use for 2 months, twice a day. Researchers will compare the two groups whether there are siginificant improvement of skin moisture and elasticity for participants via skin measurement and anaysis system.
This is a two arms, randomized, double-blind controlled trial. Study product plus collagen supplement and placebo product but without collagen will be randomly assigned to 70 eligible participants who will be enrolled at two study sites in Shanghai. Participants need to use the assigned product one bottle (25ml) each time, twice a day and visit the study site for three times (baseline day, day 30 and day 60) during the 2-month study. For each visit, the primary outcomes (skin hydration and skin elasticity) and secondary outcomes (skin barrier, lines/wrinkles, and facial glow,etc.) will be measured with professional equiment and imaging system and recorded to data management system. At the end of the study, the study data will exported and analyzed to validate the assumption that the collagen could improve skin moisture content and elasticity in middle-aged women of 30-50 years old.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
SUPPORTIVE_CARE
Masking
DOUBLE
Enrollment
70
the participant in this arm will use the assigned product 25ml one time, twice a day.
the participant in this arm will use the assigned product 25ml one time, twice a day.
Ai'er Hospital
Shanghai, Shanghai Municipality, China
SPRIM Central Lab
Shanghai, Shanghai Municipality, China
Skin Elasticity
The changes of skin elasticity by CK Cutometer MPA580
Time frame: baseline day 0, day 30, day 60
Skin Moisture
The changes of skin moisture by Corneometer CM 825
Time frame: baseline day 0, day 30, day 60
Skin Barrier
The changes of skin barrier in terms of TEWL (Trans Epidermal Water Loss) by Aquaflux F200
Time frame: baseline day 0, day 30, day 60
Lines/Wrinkles
The changes of the lines/wrinkles on the face by Miravex Antera 3D imaging system
Time frame: baseline day 0, day 30, day 60
Skin Diagnosis
The skin diagnosis (4 modes and 2 side views) with VISIA CR Facial Imaging System
Time frame: baseline day 0, day 30, day 60
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