Effect of Caffeine Versus Probiotic on Preterm Neonates With Bronchopulmonary Dysplasia

Inclusion Criteria: * Male and female preterm neonates less than 37 weeks gestational age. * Suffering from Bronchopulmonary dysplasia (BPD) diagnosed as follow: * History: Preterm infant with persistence oxygen dependency up to 28 days of life. * Clinical signs: increase work of breathing, increase oxygen requirements , increase in apnea , bradycardia and retraction. * Laboratory: arterial blood gases and electrolytes. * Radiology: streaky interstitial markings, patchy atelectasis , intermingled with cystic areas and severe lung hyperinflation. Exclusion Criteria: * Term and post term neonates * Neonates with congenital infections * Neonates with major congenital anomalies