Prospective Study to Validate the Clinical Accuracy of the Norbert Device to Measure Oxygen Saturation

Inclusion Criteria: * Healthy, male or female subjects between the ages of 18 to 50 years * Completion of a health screening for a medical history by a licensed physician, nurse practitioner, or physician assistant * Previously measured hemoglobin electrophoresis with normal result recorded in Duke Epic EHR * Minimum weight 40kg; BMI within range 18.0 - 35.0 * Assigned American Society of Anesthesiologists (ASA) Physical Status 1 by Principal Investigator or delegate Exclusion Criteria: * Prior or known allergies to lidocaine (or similar pharmacologic agents, e.g., Novocain) * Prior known severe allergies to medical grade adhesive/tape (Band-Aid) * Taking any medication other than birth control * Is currently participating in, or has recently participated in (discontinued within 30 days prior to the hypoxia procedure for this study) in an investigational interventional drug, device, or biologic study * Has a negative Allen's Test to confirm non patency of the collateral artery * Has made a whole blood donation or has had at least 450 ml of blood drawn within 8 weeks prior to the study procedure * Is female with a positive urine pregnancy test, or is female and is unwilling to use effective birth control between the time of screening and study procedure or is breast feeding * Has anemia * Has heparin allergy * Has a history of sickle cell trait or thalassemia \[self-reported\] * Has a positive urine cotinine test or urine drug screen or oral ethanol test * Has a room air saturation less than 95% by pulse oximetry * Has a clinically significant abnormal EKG * Has a COHb greater than 3%, or MetHb greater than 2% * Students and Employees under the direct supervision of PI or Sub-I