Dietary lauric acid supplementation could have a significant impact on the HIV reservoir in antiretroviral-treated patients by inducing HIV viral transcription in latently infected cells and preserving the HIV-specific immune response, without causing toxicity. Design: Pilot, randomized, placebo-controlled, patient-blind study. Patients ≥18 years old with HIV-1 receiving stable ART (no change in ART for at least 6 months) and a serum HIV RNA load of \< 50 RNA copies/mL for at least 2 years and with a CD4 T cell count \>300 cells/μl will be randomized 1:1:1 to dietary supplementation with placebo (controlled group) or lauric acid 1.5 g once daily (experimental group 1) or with lauric acid 3 g once daily (experimental group 2) for 24 consecutive weeks. Primary objective: To assess the effect of dietary lauric acid supplementation, compared with placebo, on the reactivation of HIV transcription in latently infected CD4 T cells in HIV-infected patients on suppressive antiretroviral therapy.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
SINGLE
Enrollment
27
Dietary suplementation
Lauric acid 1.5 grams once daily
Lauric acid 3 grams once daily
Hospital Universitario Vall d´Hebron
Barcelona, Spain
RECRUITINGEffective of lauric acid in HIV
Number of patients on a lauric acid diet presenting a response on the reactivation of HIV transcription in CD4 T cells.
Time frame: 48 weeks
Effective of lauric acid on the size of the latent HIV-1 reservoir in CD4 T cells
To dertermine the effetive of lauric acid on the size of the latent HIV-1 reservoir in CD4 T cells
Time frame: 48 weeks
Effective of lauric acid on the production of HIV-1 viral
To dertermine the effetive of lauric acid on on the production of HIV-1 viral (viral load)
Time frame: 48 weeks
Effective of lauric acid on the size of the HIV-1 reservoir in intestinal tissue
To dertermine the effetive of lauric acid on the size of the HIV-1 reservoir in intestinal tissue
Time frame: 48 weeks
Evaluate Lauric acid plasmatic levels
To evaluate Lauric acid with high performance liquid chromatography (HPLC).
Time frame: 48 weeks
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