The REBUILD Trial: Closure of the Abdominal Wall

Inclusion Criteria: 1. Patient is 22-80 years of age 2. Patient is undergoing a midline laparotomy procedure 3. Patient is able to provide written informed consent 4. Patient is able and willing to comply with all study requirements Exclusion Criteria: 1. Patient has BMI \> 40 2. Patients with available imaging measuring abdominal wall thickness \< 5.7 mm or \> 16.5 mm 3. Patient is scheduled for a palliative procedure or has a life expectancy of less than 12-months 4. Patient has mesh at the site of deployment 5. Patient has an ostomy within the planned midline closure site (4 cm either side of midline) 6. Patient has a CDC wound classification of Class IV 7. Patient has devitalized tissue present at the intended surgical site 8. Patient has any co-morbid conditions determined by the investigator to place them at a high risk of complications (e.g., severe cardiovascular disease, congestive heart failure NYHA Class III or IV, end-stage renal failure, liver cirrhosis, connective tissue disorder, poorly managed diabetes) 9. Patient is on any medication that the investigator determines creates a high risk for complications (e.g., antithrombotic, steroid, IV chemotherapy, immunosuppressive agent) 10. Patient has history of radiation therapy targeting the abdominal wall 11. Patient is participating in a concurrent investigational medical device study 12. Patient is pregnant or planning on becoming pregnant during the study period 13. Patient has a history of psychological condition, drug, or alcohol misuse which may interfere with their ability to be compliant with post-operative visits