Dexmedetomidine Plus Low Dose Morphine Versus Standard Dose of Morphine in PCA in Children .

Beni-Suef University60 enrolled

Overview

The treatment of perioperative pain in children has been a topic of great interest to pediatricians, pediatric surgeons, and anesthesiologists for many years. Opioids are the most common analgesics used to manage acute postoperative pain in children and adults

Patient-controlled analgesia (PCA) permits patients to self-administer small doses of opioid analgesics intravenously or subcutaneously at frequent intervals. PCA is used in the management of moderate-to-severe pain. Patient-controlled analgesia (PCA) is now used in children as young as 5 yr for the treatment of postoperative pain.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

DOUBLE

Enrollment

Conditions

PCA Children Dexmedetomidine Morphine

Interventions

standard dose morphineDRUG

Receiving 0.05 mg morphine/kg as a bolus.

low dose morphine plus dexmedetomidineDRUG

Receiving 0.02 mg morphine/kg as a bolus dose + 0.2 microgram/kg dexmedetomidine

Eligibility

Sex: ALLMin age: 8 YearsMax age: 12 Years

Medical Language ↔ Plain English

Inclusion Criteria: 1. ASA I \& II of both sex. 2. Age between 8 and 12 years. 3. Patients scheduled for exploration surgery under general anesthesia. Exclusion Criteria: 1. Parents refused to give consent. 2. Patients with history of allergy to morphine or dexmedetomidine. 3. Mental disorders. 4. Unsuitability for extubation. 5. Comorbidities as cardiac, pulmonary and obstructive sleep apnea. 6. children with chronic opioid use for \> 3 monthes

Locations (1)

Benisuef University Hospital

Egypt, Egypt

RECRUITING

Outcomes

Primary Outcomes

Post-operative pain intensity evaluation at (0,1, 2,6,12, 24h).

visual analogue score consists of a straight 10 cm line with the end points defining extreme limits between (0) no pain and (10) worst pain, the score is determined by measuring the distance between no pain and worst pain.

Time frame: 24 hour

Secondary Outcomes

Total morphine consumption in 24h postoperative.

total morphine dose in 24h

Time frame: 24 hour

sedation

(0 = awake; 1 = drowsy; 2 = asleep but arousable; 3 = deeply asleep). Patients were considered sedated if they had a sedation score of more than 0.

Time frame: 24 hour

respiratory depression

respiratory depression, if respiratory rate less than 10 breaths/minute

Time frame: 24 hour

nausea vomiting

Nausea and vomiting was recorded using a categorical scoring system (0 = none, 1 = nausea, 2 = retching, 3 = vomiting).

Time frame: 24 hour

Central Contacts

Mariana abdelsayed Mansour, MD

CONTACT

01222960009 mrmrsyk4@gmail.com

Data from ClinicalTrials.gov

This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.