The goal of this study is to compare coconut oil and sunflower seed oil derived isosorbide disesters and colloidal oatmeal, and observe their effect on pediatric atopic dermatitis among males and females aged 2-17.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
TRIPLE
Enrollment
40
Isosorbide Diesters (with 0.1% colloidal oatmeal) + Topical Hydrocortisone 2.5% ointment
Topical vehicle (with 0.1% colloidal oatmeal) + Topical Hydrocortisone 2.5 % ointment
Integrative Skin Science and Research
Sacramento, California, United States
RECRUITINGEczema Area and Severity Index (EASI)
Percent Achieving EASI 75
Time frame: 8 Weeks
Itch
Change in the Itch Visual Analog Scale from Baseline
Time frame: 8 Weeks
Eczema Area and Severity Index (EASI)
Change in the EASI score
Time frame: 1 Week
Eczema Area and Severity Index (EASI)
Change in the EASI score
Time frame: 4 Weeks
Eczema Area and Severity Index (EASI)
Change in the EASI score
Time frame: 8 Weeks
Itch
Change in the Itch Visual Analog Scale
Time frame: 1 Week
Itch
Change in the Itch Visual Analog Scale
Time frame: 4 Weeks
Topical steroid use
Cumulative use of topical steroid use
Time frame: 1 Week
Topical steroid use
Cumulative use of topical steroid use
Time frame: 4 Weeks
Topical steroid use
Cumulative use of topical steroid use
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Time frame: 8 Weeks
Skin Transepidermal Water Loss (TEWL)
TEWL measured with a Vapometer
Time frame: 1 Week
Skin Transepidermal Water Loss (TEWL)
TEWL measured with a Vapometer
Time frame: 4 Weeks
Skin Transepidermal Water Loss (TEWL)
TEWL measured with a Vapometer
Time frame: 8 Weeks
Skin Hydration
Level of skin hydration measured SkinMoistureMeterSC
Time frame: 1 week
Skin Hydration
Level of skin hydration measured SkinMoistureMeterSC
Time frame: 4 weeks
Skin Hydration
Level of skin hydration measured SkinMoistureMeterSC
Time frame: 8 weeks
Shift in the Skin Microbiome
Change in the relative abundance of Staphylococcus aureus on the skin
Time frame: 8 weeks