The present study aimed to investigate the effect of green coffee bean extract (GCBE) on the inflammatory biomarkers in obese patients with a metabolic syndrome via analyzing some inflammatory biomarkers as resistin, TNF-α, total sialic acid, homocysteine, high sensitivity C-reactive protein (hs-CRP) and anti-inflammatory cytokine, adiponectin
160 obese patients supplemented with either GCBE capsules (800 mg) daily or placebo for 6 months and advised to take a balanced diet. Blood samples were collected at baseline and after three months of supplementation
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
SUPPORTIVE_CARE
Masking
DOUBLE
Enrollment
160
supportive treatment
Placebo capsule
Naglaa Khedr
Tanta, Gharbia Governorate, Egypt
Adiponectin (µg/mL)
Serum Level
Time frame: six months
TNF-α (pg/mL)
Serum Level
Time frame: six months
Resistin (ng/mL)
Serum Level
Time frame: six months
Homocysteine (µmol/L)
Serum Level
Time frame: six months
Hs-CRP (mg/L)
Serum Level
Time frame: Six months
BMI (kg/m2)
Weight / hight squared.
Time frame: six months
LDL-C (mg/dL)
calculated according to Friedewald formula.
Time frame: six Months
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