Association Between Post-covid Infection Status and Perioperative Morbidity: A Ambispective Cohort Study

Peking Union Medical College Hospital4,000 enrolled

Overview

With the knowledge of currently transmitted omicron variant being less virulent, over 90 percent of the Chinese population is fully vaccinated, and the Chinese health workers have sufficient experience treating the illness. China 's epidemic prevention and control has entered a new stage to restore the normal functioning of society and basic medical services, On Dec, 7, China released a circular on further optimizing its COVID-19 response, announcing 10 new prevention and control measures.This has marked the watershed for sharply increased number of elective surgical patients diagnosed with COVID-19 during preoperativley, fully recovered or during recovery. Beijing faced a wave of omicron infection starting that would result in of a wide range of population infections. At which time there is limited evidence regarding the optimal timing of surgery following SARS-CoV-2 infection especially for omiron among Chinsese patients .This study intends to explore the relationship between the incidence of postoperative complications after elective surgery and COVID-19 infection in Peking Union Medical College Hospital, and provide data support for the policy formulation of elective surgical timing for patients after COVID-19 infection.

Study Type

OBSERVATIONAL

Enrollment

4,000

Conditions

COVID-19 Complication of Anesthesia Complication of Surgical Procedure Complication,Postoperative

Eligibility

Sex: ALL

Medical Language ↔ Plain English

Inclusion Criteria: 1\. All patients having pre-operative SARS-CoV-2 infection diagnosis Dec 1st 2022 to Feb 28th 2023. \[The COVID-19 diagnosis is based on either (a) a positive RT-PCR nasopharyngeal swab, (b) positive antigen rest before surgery, or (c) clinical diagnosis made before surgery\]. Exclusion Criteria: 1. Patients diagnosed with SARS-CoV-2 infection on the day of surgery or during postoperative days. 2. Day surgery or outpatient surgery. 3. Patients unwilling to participate or provide COVID-19-related information.

Outcomes

Primary Outcomes

Perioperative complications

The composite primary outcome included pulmonary complications (pneumonia, acute respiratory distress syndrome, or acute respiratory failure, reintubation, unplanned use or prolongation of postoperative mechanical ventilation), cardiovascular complications (deep vein thrombosis, pulmonary embolism, myocardial infarction, newly onset arrhythmia, ischemic stroke, and acute kidney injury), and infectious complications other than pulmonary infection (urinary tract infection, surgical site infection, and sepsis).

Time frame: During the procedure