Opium Tincture Against Chronic Diarrhea - Patients

Inclusion Criteria: * • Signed informed consent before any study specific procedures * Able to read and understand Danish * Male or female with an age of 20 years or more * The researcher believes that the participant understands what the study entails, are capable of following instructions, can attend when needed, and are expected to complete the study. * The investigator will ensure that fertile female participants have a negative pregnancy test before each treatment visit and use contraception during the entity of the study. * Specific underlying pathophysiology has been identified, but targeted treatment (e.g. antibiotics or bile acid sequestrants) and treatment with loperamide has failed. OR * No specific underlying pathophysiology has been identified and treatment with loperamide has failed. * At least 6 months post-surgery in the gastrointestinal tract * No sign of cancer at standard clinical follow-up * Chronic diarrhea defined as at least 3 daily bowel movements for the last week Exclusion Criteria: * • Known allergy towards pharmaceutical compounds similar to Dropizol. * Participation in other studies within 14 days of first visit (1 year if opioids involved). * Expected need of medical/surgical treatment during the study * History of psychiatric illness (e.g. mental retardation, schizophrenia, major depression) * History of substance abuse (e.g. alcohol, THC, benzodiazepine, central stimulants and/or opioids) * Family history of substance abuse * Known major stenosis of the intestines * Known severe decreased renal function (defined as eGFR below 30) * Known severe decreased hepatic function (defined as Child-Pugh class B or higher) * Treatment with MAO- inhibitors during the entity of the study * Severe COPD or acute severe asthma (defined as FEV1 below 50 % or acute ongoing exacerbation) * Known cor pulmonale * Female participants that are lactating * Medicine known to affect gastrointestinal motility must not be initiated during the entity of the study * Treatment with opium tincture during the last month