Non-contrast Abbreviated MRI for Secondary Surveillance of HCC

Seoul National University Hospital210 enrolled

Overview

This prospective multicenter study aimed to compare the diagnostic performance of non-contrast abbreviated MRI in detecting recurrent HCC after curative treatment to that of contrast-enhanced liver CT.

This study was designed as a prospective single-arm intra-individual comparison multicenter study

Study Type

OBSERVATIONAL

Enrollment

210

Conditions

Hepatocellular Carcinoma

Interventions

non-contrast abbreviated MRIDIAGNOSTIC_TEST

Liver MRI without contrast injection. The following sequences will be obtained from all of the participants. * Axial heavily and regular T2 WI * precontrast fat-suppressed T1 WI * Diffusion-weighted image using b-value of 0, 50 or 400, and 800 or 1000

Contrast enhanced liver CTDIAGNOSTIC_TEST

Liver CT with iodine contrast injection This test will be served as a standard diagnostic test. The following phases will be obtained * precontast, arterial phase, portal venous phase and delayed phase

Eligibility

Sex: ALLMin age: 20 YearsMax age: 85 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Age between 20-year old and 85-year old * Patients with a history of curative treatment for HCC including surgical resection or local ablation * No recurrence after curative treatment of HCC for more than two years * Patient who has the plan to perform contrast-enhanced liver CT for secondary surveillance for HCC (i.e., to detect de novo or recurrent HCC) Exclusion Criteria: * Estimated GFR less than 60 * Previous history of severe allergic reaction to the iodinated contrast agent * Patients with claustrophobia who can't undergo MR examination * Patients having cochlear implants or cardiac pacemaker

Locations (3)

Seoul National University Bundang Hospital

Seongnam, Korea (the Republic Of), South Korea

Asan Medical Center

Seoul, Korea (the Republic Of), South Korea

Seoul National University Hospital

Seoul, South Korea

Outcomes

Primary Outcomes

Accuracy per patient

Accuracy for detection of recurrent HCC per patient

Time frame: Within 6 months from the study completion

Secondary Outcomes

Specificity per patient

Specificity for detection of recurrent HCC per patient

Time frame: Within 6 months from the study completion

Sensitivity per patient

Sensitivity for detection of recurrent HCC per patient

Time frame: Within 6 months from the study completion

Data from ClinicalTrials.gov

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