The main objective is to study the effect of engineered nanoparticles SPIONs (superparamagnetic iron oxide) on hemostasis. Nanoparticles will be incubated in blood and platelet aggregation will be measured. In parallel, nanoparticles will also be incubated in blood and then plasma proteins adsorbed on them will be separated and analyzed. The proteins found on the nanoparticles will be linked to the platelet aggregation observed to help developing innovative protein functionalized nanoprobes for optimized nanomedicine.
Study Type
OBSERVATIONAL
Enrollment
60
evaluate the possible impact of iron oxide nanoparticles (superparamagnetic iron oxide = SPIONs) (N=10) in the blood circulation;
CHU DIJON BOURGOGNE - laboratoire mixte
Dijon, France
impact of nanoparticles on coagulation tests ou platelet functions
Time frame: at the baseline
Difference of behaviour of the nanoparticles (N=10 preparations) on coagulation cascade and platelet functions
Time frame: at the baseline
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