Precise Transplantation of Human Amniotic Epithelial Stem Cells Into Lateral Ventricle for Parkinson's Disease

Inclusion Criteria: 1. 40-70 years old, with more than 5 years of idiopathic PD history 2. UPDRS-III off-time scores ≤49 3. MMSE scores ≥24 4. HAMD-17 scores \< 25 5. H-Y on-time scores ≤4 6. reactive to levodopa or dopa agonists 7. PD medication dose is stable for more than 2 months 8. no general anesthesia contraindications, no stereotactic surgery contraindications or other conditions that interfere with clinical evaluation 9. no abnormalities affecting cell transplantation by cranial MRI 10. no participation of other clinical trials 3 months before signing the informed consent Exclusion Criteria: 1. secondary PD or Parkinson's syndrome 2. subcutaneous apomorphine treatment 3. scoring ≥ 2 on UPDRS-I item 2, or ≥ 2 on UPDRS-II item 13; or ≥ 3 on UPDRS-II item14 4. history of intracranial surgery or device implantation, including deep brain stimulation, within 2 years prior to signing informed consent 5. history of seizures or prophylactic application of antiepileptic drugs 6. other serious central nervous system disorders 7. history of stem cell therapy 8. subject who had undergone a major surgery within 3 months and will undergo a major surgery within the next 6 months prior to signing informed consent 9. autoimmune disease or current use of Immunosuppressants 10. subjects with comorbid cardiac disease, for example, but not limited to, ischemic heart disease, congestive heart failure, significant arrhythmias or cardiac conduction block 11. poorly controlled hypertension, diabetes mellitus, or comorbid endocrine system disorders, pulmonary disorders, gastrointestinal system disorders, serious infections, malignancies, etc. 12. positive for hepatitis B surface antigen (HBsAg), hepatitis C virus (HCV) antibodies, human immunodeficiency virus (HIV) antibodies, or Treponema pallidum antibody 13. abnormalities in liver or kidney function tests, including alanine aminotransferase (ALT), aspartate aminotransferase (AST) is less than 2.5 times the upper limit of normal, blood urea nitrogen (BUN) or creatinine(Cr) are less than 1.5 times the upper limit of normal, or serum albumin \< 30.0 g/L 14. abnormalities in hematologic test: coagulation disorders or ongoing anticoagulation therapy; moderate to severe anemia; platelet count \< 80 × 10\^9/L 15. inability to undergo MRI and positron emission tomography (PET) examinations 16. subject with severe allergies 17. women of childbearing potential (WOCBP) or subject is a man with a WOCBP partner, who are unwilling to take contraception during the trial 18. pregnant or lactating females 19. other conditions deemed by the investigator to be inappropriate for enrollment.