Assessment of the Effect of Non-surgical Periodontal Treatment on Endothelial Function- a Prospective Study

University of Sharjah40 enrolled

Overview

An association between periodontitis and endothelial dysfunction has been reported, suggesting that periodontitis presents an inflammatory burden to the cardiovascular system, that might lead to AVD. The study aims aim to assess whether non-surgical periodontal therapy enhances endothelial function in periodontitis patients using a non-invasive diagnostic device to assess endothelial function through PWA and the assessment of levels of salivary Endothelin-1, in a population of people in the UAE.

Study Type

OBSERVATIONAL

Enrollment

Conditions

Endothelial Dysfunction Periodontal Diseases

Interventions

Assessment of pulse wave amplitude (PWA)DIAGNOSTIC_TEST

Assessment of pulse wave amplitude (PWA) through peripheral arterial tonometry (PAT) using the device EndoPAT (Itamar Medical)

Eligibility

Sex: ALLMin age: 18 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Group 1: periodontally healthy subjects. * Group 2: patients with periodontitis stage III or IV and grades A,B or C. Exclusion Criteria: * Medical conditions: Diabetes,pregnancy,obesity,renal disease,patients with cardiovascular diseases including hypertension,recent myocardial infarction or unstable angina (within 3 months),congestive heart failure,valvular heart disease * Heavy smokers(\>10 cigarettes per day), * Regular administration of drugs resulting in gingival hyperplasia,root planning in the past 6 months * Regular administration of drugs resulting in gingival hyperplasia (such as cyclosporine and phenytoin) * Recent antibiotic use (in the past 3 months) * Non-surgical periodontal therapy in the past 6 monthsp

Assessment of the Effect of Non-surgical Periodontal Treatment on Endothelial Function- a Prospective Study

Overview

Conditions

Interventions

Eligibility

Locations (1)

Outcomes

Primary Outcomes

Central Contacts