The Pancreas Interception Center (PIC) for Early Detection, Prevention, and Novel Therapeutics

N/AActive Not RecruitingNCT05692596

H. Lee Moffitt Cancer Center and Research Institute317 enrolled

Overview

The long-term goal of our PIC is to develop effective strategies that can be applied clinically at the point-of-care to prevent, intercept, or detect PDAC at an early stage, thereby reducing PDAC burden and saving lives.

Study Type

OBSERVATIONAL

Enrollment

317

Conditions

Pancreatic Ductal Adenocarcinoma Pancreatic Cyst Chronic Pancreatitis Fatty Pancreas Genetic Pancreatic Cancer Genetic Pancreatitis BRCA Mutation Lynch Syndrome FAP

Interventions

Data collectionOTHER

Investigators will compile data typically collected clinically. This data will include demographics, cancer screening procedures, cancer diagnosis and staging, chemotherapy, immunotherapy, radiation therapy, surgery, comorbidities, medication use, lifestyle and other cancer risk factors, quality of life, vital status, and molecular data generated from specimens collected clinically.

Eligibility

Sex: ALLMin age: 18 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * 18 years of age or older * Moffitt Cancer Center patients presenting with a pancreatic cyst, and/or inherited syndrome that predisposes them to pancreatic ductal adenocarcinoma (PDAC) * Moffitt Cancer Center patients undergoing evaluation for localized/early stage PDAC. * Moffitt Cancer Center patients with a combination of PDAC risk factors such as a history of chronic or new-onset diabetes, pancreatitis, obesity, tobacco exposure, toxin exposure and/or heavy alcohol consumption.

Outcomes

Primary Outcomes

Database creation

A centralized, real-time, queryable and secure database will be developed that will integrate data on Moffitt patients diagnosed with pancreatic ductal adenocarcinoma (PDAC), pancreatic cystic lesions (benign, pre-cancerous and malignant), or an inherited PDAC susceptibility.

Time frame: 24 months

Data from ClinicalTrials.gov

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