Clinical Trial To Determine The Effectiveness And Safety Of Topical Insulin In Dry Eye

Inclusion Criteria: * Patients older than 18 years * Dry eye disease diagnosis * Treatment with artificial tears or hyaluronic acid gels for at least 3 months * Signed informed consent by the patient * Staining equal to or greater than Oxford II Exclusion Criteria: * Under 18 years old * Corneal staining under Oxford II * Treatment for dry eye disease other than artificial tears or hyaluronic acid gels * Severe dry eye disease that requires immediate treatment * Eye surgery in the last 6 months * Other concomitant corneal pathology, eyelid malpositions, nasolacrimal drainage abnormalities, blinking alterations * Contact lenses * Other treatment besides artificial tears or hyaluronic acid gels * Visual acuity less than 0.1 * Allergy or intolerance to any of the components included in the study * Modifications in systemic immunosuppressive treatment * Pregnancy or lactation * Women of childbearing age who do not use a highly effective contraceptive method * History of alcohol or drug abuse * Participation in another clinical trial in the last 30 days * Systemic pathology (cardiopulmonary pathology, connective tissue disorders, neurological or psychiatric pathology) or baseline situation of the patient that does not allow the examination (such as mental or psychomotor retardation)