Muscle Memory After Treatment With Anabolic Substance Clenbuterol and Resistance Training in Humans

Morten Hostrup, PhD60 enrolled

Overview

The purpose of the project is investigate muscle memory and underlying mechanisms in humans following resistance training and use of the anabolic substance clenbuterol.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

BASIC_SCIENCE

Masking

QUADRUPLE

Enrollment

Conditions

Skeletal Muscle Physiology

Interventions

ClenbuterolDRUG

Participants ingest 80 micrograms clenbuterol daily during the initial 8-week period. This period is followed by a washout of 16 weeks with no drug and resistance training. Thereafter, an 8-week period with supervised resistance training is commenced, with no drug.

PlaceboDRUG

Participants ingest placebo tablets daily during the initial 8-week period. This period is followed by a washout of 16 weeks with no drug and resistance training. Thereafter, an 8-week period with supervised resistance training is commenced, with no drug.

Eligibility

Sex: ALLMin age: 18 YearsMax age: 40 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Healthy men and women * BMI of \<26 and normal ECG and blood pressure Exclusion Criteria: * Smoking * Chronic disease, * Use of prescription medication * Pain due to current or previous musculoskeletal injury * Resistance training more than once per week in the 12 months leading up to the intervention * Current or previous use of prohibited anabolic substances

Locations (1)

August Krogh Building

Copenhagen, Denmark

RECRUITING

Outcomes

Primary Outcomes

Fiber cross-sectional area

Immunohistochemistry to determine fiber cross-sectional area

Time frame: The change in fiber cross-sectional is assessed at baseline, 8, 24 and 32 weeks

Myonuclei

Immunohistochemistry to determine number of myonuclei

Time frame: The change in myonuclei is assessed at baseline, 8, 24 and 32 weeks

Skeletal muscle proteome

Pathway enrichment analysis of the muscle proteome using mass-spectrometry based proteomics

Time frame: The change in the muscle proteome is assessed at baseline, 8, 24 and 32 weeks

Secondary Outcomes

Lean mass

Lean mass assessed by dual X-ray absorptiometry (DXA)

Time frame: The change in lean mass is assessed at baseline, 8, 24 and 32 weeks

Isometric muscle strength

Maximal voluntary isometric contraction of m. quadriceps

Time frame: The change in maximal voluntary isometric contraction is assessed at baseline, 8, 24 and 32 weeks

Dynamic muscle strength

1-repetition maximum

Time frame: The change in 1-repetition maximum is assessed at baseline, 8, 24 and 32 weeks

Sprint performance

Work performed (W) during a sprint on a bicycle ergometer

Time frame: The change in sprint performance is assessed at baseline, 8, 24 and 32 weeks

Satellite cells

Central Contacts

Morten Hostrup

CONTACT

+4535321595 mhostrup@nexs.ku.dk

Data from ClinicalTrials.gov

This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.