The purpose of this waitlist-controlled, single-blind, one-way crossover, pilot trial is to evaluate the potential effects of \~8 weeks of chiropractic care on patient-reported fatigue and the autonomic nervous system in adults with long COVID. This study will allow us to estimate the standard deviation of the primary endpoint in our population with which a formal power calculation for a future randomized, controlled trial can be performed.
After providing informed consent, participants will be placed on an 8-week waitlist followed by 8 weeks of chiropractic care. In-person assessments will occur 5 times: Day 1, following 2-3 weeks on waitlist, following 8 weeks on waitlist, following 2-3 weeks of chiropractic care, and following 8 weeks of chiropractic care. Patient-reported outcomes will additionally be sent prior to the first in-person assessment (Day 0). Assessments will include the following: 1. Seated resting recording 2. Sit-to-stand test 3. Patient-reported outcome surveys Each assessment will consist of the following recordings: 1. Electroencephalography \[EEG\] 2. Impedance cardiography \[ICG\] 3. Electrocardiogram \[ECG\]
Study Type
INTERVENTIONAL
Allocation
NA
Purpose
TREATMENT
Masking
NONE
Enrollment
40
wait-list
chiropractic adjustments
Lydian Chiropractic LLC
Cambridge, Massachusetts, United States
FACIT fatigue scale
Patient Reported Outcome - The FACIT Fatigue Scale is a short, 13-item, easy to administer tool that measures an individual's level of fatigue during their usual daily activities over the past week. The level of fatigue is measured on a 4-point Likert scale (4 = not at all fatigued to 0 = very much fatigued)
Time frame: Preliminary
FACIT fatigue scale
Patient Reported Outcome - The FACIT Fatigue Scale is a short, 13-item, easy to administer tool that measures an individual's level of fatigue during their usual daily activities over the past week. The level of fatigue is measured on a 4-point Likert scale (4 = not at all fatigued to 0 = very much fatigued)
Time frame: Baseline (Day 1)
FACIT fatigue scale
Patient Reported Outcome - The FACIT Fatigue Scale is a short, 13-item, easy to administer tool that measures an individual's level of fatigue during their usual daily activities over the past week. The level of fatigue is measured on a 4-point Likert scale (4 = not at all fatigued to 0 = very much fatigued)
Time frame: 2-3 weeks on wait-list
FACIT fatigue scale
Patient Reported Outcome - The FACIT Fatigue Scale is a short, 13-item, easy to administer tool that measures an individual's level of fatigue during their usual daily activities over the past week. The level of fatigue is measured on a 4-point Likert scale (4 = not at all fatigued to 0 = very much fatigued)
Time frame: 8 weeks on wait-list
FACIT fatigue scale
Patient Reported Outcome - The FACIT Fatigue Scale is a short, 13-item, easy to administer tool that measures an individual's level of fatigue during their usual daily activities over the past week. The level of fatigue is measured on a 4-point Likert scale (4 = not at all fatigued to 0 = very much fatigued)
Time frame: 2 - 3 weeks following start of intervention
This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.
FACIT fatigue scale
Patient Reported Outcome - The FACIT Fatigue Scale is a short, 13-item, easy to administer tool that measures an individual's level of fatigue during their usual daily activities over the past week. The level of fatigue is measured on a 4-point Likert scale (4 = not at all fatigued to 0 = very much fatigued)
Time frame: Post intervention
EEG resting state broadband power
256-channel hydronet cap
Time frame: Baseline (Day 1)
EEG resting state broadband power
256-channel hydronet cap
Time frame: 2-3 weeks on wait-list
EEG resting state broadband power
256-channel hydronet cap
Time frame: 8 weeks on wait-list
EEG resting state broadband power
256-channel hydronet cap
Time frame: 2 - 3 weeks following start of intervention
EEG resting state broadband power
256-channel hydronet cap
Time frame: Post intervention
EEG resting state functional connectivity
256-channel hydronet cap
Time frame: Baseline (Day 1)
EEG resting state functional connectivity
256-channel hydronet cap
Time frame: 2-3 weeks on wait-list
EEG resting state functional connectivity
256-channel hydronet cap
Time frame: 8 weeks on wait-list
EEG resting state functional connectivity
256-channel hydronet cap
Time frame: 2-3 weeks following start of intervention
EEG resting state functional connectivity
256-channel hydronet cap
Time frame: Post intervention
ECG mean interbeat interval
3 sensors on torso
Time frame: Baseline (Day 1)
ECG mean interbeat interval
3 sensors on torso
Time frame: 2-3 weeks on wait-list
ECG mean interbeat interval
3 sensors on torso
Time frame: 8 weeks on wait-list
ECG mean interbeat interval
3 sensors on torso
Time frame: 2-3 weeks following start of intervention
ECG mean interbeat interval
3 sensors on torso
Time frame: Post intervention
ECG respiratory sinus arrhythmia (RSA)
3 sensors on torso
Time frame: Baseline (Day 1)
ECG respiratory sinus arrhythmia (RSA)
3 sensors on torso
Time frame: 2-3 weeks on wait-list
ECG respiratory sinus arrhythmia (RSA)
3 sensors on torso
Time frame: 8 weeks on wait-list
ECG respiratory sinus arrhythmia (RSA)
3 sensors on torso
Time frame: 2-3 weeks following start of intervention
ECG respiratory sinus arrhythmia (RSA)
3 sensors on torso
Time frame: Post intervention
Impedance cardiogram (ICG) pre-ejection period (PEP)
2 sensors on chest and 2 sensors on back
Time frame: Baseline (Day 1)
Impedance cardiogram (ICG) pre-ejection period (PEP)
2 sensors on chest and 2 sensors on back
Time frame: 2-3 weeks on wait-list
Impedance cardiogram (ICG) pre-ejection period (PEP)
2 sensors on chest and 2 sensors on back
Time frame: 8 weeks on wait-list
Impedance cardiogram (ICG) pre-ejection period (PEP)
2 sensors on chest and 2 sensors on back
Time frame: 2-3 weeks following start of intervention
Impedance cardiogram (ICG) pre-ejection period (PEP)
2 sensors on chest and 2 sensors on back
Time frame: Post intervention
Impedance cardiogram (ICG) initial systolic time interval (ISTI)
2 sensors on chest and 2 sensors on back
Time frame: Baseline (Day 1)
Impedance cardiogram (ICG) initial systolic time interval (ISTI)
2 sensors on chest and 2 sensors on back
Time frame: 2-3 weeks on wait-list
Impedance cardiogram (ICG) initial systolic time interval (ISTI)
2 sensors on chest and 2 sensors on back
Time frame: 8 weeks on wait-list
Impedance cardiogram (ICG) initial systolic time interval (ISTI)
2 sensors on chest and 2 sensors on back
Time frame: 2-3 weeks following start of intervention
Impedance cardiogram (ICG) initial systolic time interval (ISTI)
2 sensors on chest and 2 sensors on back
Time frame: Post intervention
Patient-reported outcomes
4 questionnaires - MFSI, IPAQ-S, PSS-4, C19-YRSm
Time frame: Preliminary
Patient-reported outcomes
4 questionnaires - MFSI, IPAQ-S, PSS-4, C19-YRSm
Time frame: Baseline (Day 1)
Patient-reported outcomes
4 questionnaires - MFSI, IPAQ-S, PSS-4, C19-YRSm
Time frame: 2-3 weeks on wait-list
Patient-reported outcomes
5 questionnaires - MFSI, IPAQ-S, PSS-4, C19-YRSm, GRC
Time frame: 8 weeks on wait-list
Patient-reported outcomes
4 questionnaires - MFSI, IPAQ-S, PSS-4, C19-YRSm
Time frame: 2-3 weeks following start of intervention
Patient-reported outcomes
5 questionnaires - MFSI, IPAQ-S, PSS-4, C19-YRSm, GRC
Time frame: Post intervention